Yazar "Kaya, Betül" için listeleme
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Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
Kaya, Betül; Hussin, Weiam; Yurttaş, Leyla; Turan, Gülhan; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Georg Thieme Verlag Kg, 2017)Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ... -
New Cyclohexylamine-dithiocarbamate Derivatives as Potential Anti-microbial Agents
Yurttaş, Leyla; Kaya, Betül; Cankılıç, Meral Yılmaz; Levent, Serkan (Bentham Science Publ LTD, 2017)Background: In this study, 2-(substituted-sulfanyl)-N, N-dicyclohexylacetamide derivatives (2a-2g) and 2-(dicyclohexylamino)-2-oxoethyl-1-substituted carbodithioate derivatives (2h-2m) were synthesized and screened for ... -
Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
Kaya, Betül; Yurttaş, Leyla; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2017)In the present study, a new series of 2-[4-(pyrimidin-2-yl) piperazin-1-yl]-2-oxoethyl 4-substituted piperazine- 1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory ... -
Pirimidin içeren bazı yeni 2,5-disübstitüe 1,3,4-oksadiazol türevlerinin sentezi ve sitotoksik ajan olarak değerlendirilmesi
Amaç: Kansere karşı günümüzde kullanılan ilaçların ilaç direnci, toksisite ve düşük biyoyararlanım gibi advers etkilerden dolayı, tedavide yeni antikanser ajanların varlığına ihtiyaç duyulmaktadır. Bu çalışmada pirimidin ... -
Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives
Kaya, Betül; Özkay, Yusuf; Temel, Halide Edip; Kaplancıklı, Zafer Asım (Hindawi LTD, 2016)Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N'-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide ... -
Synthesis and biological evaluation of some new pyrimidine bearing 2,5-disubstituted 1,3,4-oxadiazole derivatives as cytotoxic agents
Kaya, Betül; Kaplancıklı, Zafer Asım; Yurttaş, Leyla; Çiftçi, Gülsen Akalın (Walter De Gruyter GMBH, 2017)Objective: As a result of adverse effects including drug-resistance, toxicity and low bioavailability, there has been a crucial need for novel anticancer agents. In this present study, some novel 2,5-disubstituted ... -
Synthesis of some novel 2-substituted benzothiazole derivatives containing benzylamine moiety as monoamine oxidase inhibitory agents
Kaya, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)In the present work, 12 new 2-(5-substituted-benzothiazol-2-ylsulfanyl)-N-(substitutedbenzyl)-N-(4-substitutedphenyl) acetamide derivatives (4a-l) was designed and synthesized. The structures of the synthesized compounds ...
