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Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line
Başpınar, Mustafa Serhat; Özyurt, Rumeysa; Kuş, Gökhan; Kutlay, Özden; Özkurt, Mete; Erkasap, Nilüfer; Kabadere, Selda (Comenius University, 2017)OBJECTIVE: The aim of this study was to investigate the effects of a novel anti-cancer drug, ceranib-2, which targets the acid ceramidase, in human colon cancer cell line. MATERIALS AND METHODS: The cell lines were treated ... -
Erythropoietin Protects the Kidney by Regulating the Effect of TNF-alpha in L-NAME-Induced Hypertensive Rats
Özkurt, Mete; Uzuner, Kubilay; Erkasap, Nilüfer; Kuş, Gökhan; Özyurt, Rumeysa; Uysal, Onur; Kutlay, Özden (Karger, 2018)Background/Aims: Hypertension is the leading cause of death worldwide. Chronic high blood pressure induces inflammation. Tumor necrosis factor (TNF)-alpha plays a major role in inflammation and also depresses the synthesis ... -
Hypotensive effects of carvacrol on the blood pressure of normotensive rats
Aydın, Yasemin; Kutlay, Özden; Arı, Senem; Duman, Seval; Uzuner, Kubilay; Aydın, Süleyman (Georg Thieme Verlag Kg, 2007)Carvacrol is the major compound of essential oils of many plants, ethnomedically used for centuries but there were no detailed investigations on its action on the cardiovascular system. The aim of our study was to investigate ...