Yazar "Ozturk, A. Alper" için listeleme
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Clarithromycin-Loaded Poly (Lactic-co-glycolic Acid) (PLGA) Nanoparticles for Oral Administration: Effect of Polymer Molecular Weight and Surface Modification with Chitosan on Formulation, Nanoparticle Characterization and Antibacterial Effects
Ozturk, A. Alper; Yenilmez, Evrim; Ozarda, Mustafa Gueclue (Mdpi, 2019)Clarithromycin (CLR) is a member of the macrolide antibiotic group. CLR has low systemic oral bioavailability and is a drug of class II of the Biopharmaceutical Classification System. in many studies, using nanoparticles ... -
Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by nano-spray dryer: A nanoenglobing study
Ozturk, A. Alper; Aygul, Abdurrahman (Marmara Univ, 2020)Spray drying is an important method used in pharmaceutical product manufacturing for many years. the nano-spray dryer developed in recent years provides ultrafine powders at nanoscale and high product yields. in this study, ... -
Dexketoprofen trometamol loaded solid lipid nanoparticles (SLNs): Formulation, in vitro and in vivo evaluation
Ozturk, A. Alper; Yenilmez, Evrim; Arslan, Rana; Senel, Behiye; Yazan, Yasemin (Marmara Univ, 2020)Development, in vitro and in vivo evaluation of dexketoprofen trometamol (DT)-loaded nanosized drug delivery system was aimed in this study. DT-loaded solid lipid nanoparticles (SLNs) were prepared using probe sonication. ... -
Diclofenac sodium loaded PLGA nanoparticles for inflammatory diseases with high anti-inflammatory properties at low dose: Formulation, characterization and in vivo HET-CAM analysis
Ozturk, A. Alper; Namli, Irem; Gulec, Kadri; Kiyan, H. Tuba (Academic Press Inc Elsevier Science, 2020)The development of a new drug active substance is not only time-consuming and expensive, but also a chain of operations that often fails. However, increasing the bioavailability, effectiveness, safety, or targeting the ... -
Effect of different molecular weight PLGA on flurbiprofen nanoparticles: formulation, characterization, cytotoxicity, and in vivo anti-inflammatory effect by using HET-CAM assay
Ozturk, A. Alper; Yenilmez, Evrim; Senel, Behiye; Kiyan, Hulya Tuba; Guven, Umay Merve (Taylor & Francis Ltd, 2020)Objective: the effect of polymers used in nanoparticle (NP) production on the formulation properties is one of the few studied issues. Therefore, this study aims to formulate flurbiprofen (FLB) loaded NPs with different ... -
Evaluation of carvedilol-loaded Eudragit (R) nanoparticles
Guven, Umay Merve; Ozturk, A. Alper; Yenilmez, Evrim (Marmara Univ, 2020)The objective of present study was to prepare positively charged carvedilol-loaded nanoparticles providing a controlled release formulation by spray dryer technique and was to examine the effect of different derivative of ... -
Levocetirizine Dihydrochloride-Loaded Chitosan Nanoparticles: Formulation and in Vitro Evaluation
Yurtdas Kirimlioglu, Gulsel; Ozturk, A. Alper (Turkish Pharmacists Assoc, 2020)Objectives: the aim of the present study was to formulate levocetirizine hydrochloride (LCD)-loaded chitosan nanoparticles at submicron level with high entrapment efficiency and prolonged effect for optimizing the plasma ... -
Preparation and in vitro characterization of lamivudine loaded nanoparticles prepared by acid and/or ester terminated PLGA for effective oral anti-retroviral therapy
Ozturk, A. Alper; Yurtdas Kirimlioglu, Gulsel (Marmara Univ, 2019)The aim of this study was to formulate Lamivudine (LAM) loaded poly lactic-co-glycolic acid (PLGA) nanoparticle (NP) formulations by 'double emulsion solvent evaporation' method for oral administration. PLGA with similar ... -
Treatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: Formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assay
Ozturk, A. Alper; Kiyan, H. Tuba (Academic Press Inc Elsevier Science, 2020)Angiogenesis is a fundamental process of wound healing, embryogenesis etc. but occurs in cancer and chronic inflammation pathologically. HET-CAM assay is a useful, well established and animal alternative test to screen ...
