Yazar "Temel, Halide Edip" için listeleme
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Apoptotic effects of some carbazole derivatives on lung carcinoma and glioma cell lines
Çiftçi, Gülsen Akalın; Temel, Halide Edip; Yıldırım, Şafak Ulusoylar; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Genç, Lütfi (Springer Birkhauser, 2013)In this study, we aimed to study the apoptotic effects of 2-[(9-ethyl-9H-carbazol-3-yl)amino]-2-oxoethyl N,N-disubstituted dithiocarbamates on A549 lung carcinoma and C6 glioma cell lines. Cytotoxicity analyses of DNA ... -
Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
Yurttaş, Leyla; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Sağlık, Begüm Nurpelin; Demir, Bahar; Levent, Serkan (Bentham Science Publ LTD, 2017)Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ... -
Butrylcholinesterase Activity in Chronic Liver Disease Patients and Correlation with Child-Pugh Classification and MELD Scoring System
Temel, Halide Edip; Temel, Tuncer; Cansu, Dondu Üsküdar; Özakyol, Ayşegül (Clin Lab Publ, 2015)Background: After 40 years since establishment of Child-Pugh staging, 14 years since establishment of MELD scoring system, and 25 years since establishment of King's College Criteria, there is still a search for more ... -
Chemical characterization and anticholinesterase effects of essential oils derived from Salvia species
Temel, Halide Edip; Demirci, Betül; Demirci, Fatih; Celep, Ferhat; Kahraman, Ahmet; Doğan, Musa; Başer, K. Hüsnü Can (Taylor & Francis Inc, 2016)Inhibitory effect of Salvia species herbal preparations on acetylcholinesterase (AChE) and butylcholinesterase (BuChE) activitiy may contribute to regulation of cognitive performance and impaired cholinergic functions in ... -
Comparison of apoptotic effects of lupeol on A549 and C6 cell lines
Ertorun, İpek (Anadolu Üniversitesi, 2024)Lupeol compound is a cyclic triterpene alcohol that is widely found in plants. The compound lupeol has been reported to exhibit antitumor, anti-inflammatory, anxiolytic, neuroprotective and hepatoprotective effects. Recent ... -
COX inhibitory profiles of a series of thiadiazole-benzothiazole hybrids
Anadolu Üniversitesi; 0000-0003-0280-5550; 0000-0002-5233-1165; Özdemir, Ahmet; Temel, Halide Edip (Anadolu Üniversitesi, 2024)In an endeavour to identify small molecule COX-1 inhibitors, a colorimetric assay protocol was applied for the in vitro evaluation of COX-1 and 2 inhibitory potential of a series of thiadiazole-benzothiazole hybrids. The ... -
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
Çiftçi, Gülsen Akalın; Altıntop, Mehlika Dilek; Temel, Halide Edip; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ... -
Design, synthesis and in vitro COX inhibitory profiles of a new series of tetrazole-based hydrazones
Anadolu Üniversitesi, Eczacılık Fakültesi; Altıntop, Mehlika Dilek; Sever, Belgin; Temel, Halide Edip; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Anadolu Üniversitesi, 2022)Inhibition of cyclooxygenases (COXs), by selective and nonselective inhibitors, is a favorable approach for pharmacologic intervention in a variety of disorders such as cancer. For this purpose, a new class of tetrazole-hydrazone ... -
Effect of alpha lipoic acid and silymarin on bladder outlet obstruction
Yıldırım, Abidin; Başesikoğlu, Barbaros; Temel, Halide Edip; Erkasap, Nilüfer; Yenilmez, Aydın; Uslu, Sema; Dönmez, Turgut (Spandidos Publ LTD, 2013)The aim of the present study was to determine whether the treatment of obstructed rat bladders with alpha lipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction ... -
The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats
Akyüz, Fahrettin; Tekin, Neslihan; Aydın, Özlem; Temel, Halide Edip; Işıklı, Burhanettin (Academic Journals, 2012)The objective of this study was to determine the effects of metformin treatment and exercise intervention on lipid metabolism, nitric oxide (NO), nitric oxide synthase (NOS) and glucose levels in streptozotocin-nicotinamide ... -
Effects of acetylsalicylate overdose on lipopolysaccharide-induced lung injury in rats: the role of the VEGF
Akyüz, Fahrettin; Aydın, Özlem; Aydın, Tayfun; Tekin, Neslihan; Temel, Halide Edip; Burukoğlu, Dilek; Aral, Erinç (Turkish Biochem Soc, 2012)Aim: Vascular endothelial growth factor production is decreased depending on the alveolar epithelial cell damage. Acute over expression of vascular endothelial growth factor in lung tissue contributes to the formation ... -
EFFECTS of Aspirin Overdose ON BalfVEGF of Endotoxemic Rats
Aydın, Özlem; Tekin, Neslihan; Aydın, Tayfun; Temel, Halide Edip; Burukoğlu, Dilek; Aral, Erinç; Akyüz, Fahrettin (Taylor & Francis Inc, 2010)… -
Effects of combination of p-dimethylaminoazobenzene and dioxin on serum lipid profile
Objective: The liver cancer initiator p-dimethylaminoazobenzene and the potent liver promoter Dioxin are the environmental pollutants that people may be exposed to those in their daily lives. Butyrylcholinesterase is a ... -
Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome
Uslu, S.; Özçelik, E.; Kebapçı, N.; Temel, Halide Edip; Demirci, Fatih; Ergün, Bülent; Demirüstü, C. (Springer London LTD, 2016)Background Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase ... -
The impact of klotho gene polymorphisms on urinary tract stone disease
Gürel, Abdullah; Ure, Iyimser; Temel, Halide Edip; Çilingir, Oğuz; Uslu, Sema; Celayir, Mehmet Fatih; Başesikoğlu, Ali Barbaros (Springer, 2016)To investigate the effect of klotho gene and beta-glucuronidase activity on stone formation in patients with urinary tract stone disease (UTSD). A total of 103 patients with UTSD and 102 controls with no specific urolithiasis ... -
In vitro biological and toxicological evaluation of Lathyrus sp extracts
Polatoğlu, Kaan; Göğer, Fatih; Temel, Halide Edip; Demirci, Fatih (Georg Thieme Verlag Kg, 2015)… -
Inhibitory effect of Calamintha nepeta subsp glandulosa essential oil on lipoxygenase
Demirci, Betül; Temel, Halide Edip; Portakal, Tuba; Kırmızıbekmez, Hasan; Demirci, Fatih; Başer, K. Hüsnü Can (Walter De Gruyter GMBH, 2011)Objective: Scavenging of free radicals and inhibition of lipoxygenase are important target in the treatment of a variety of inflammatory diseases. Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) P.W. Ball of Lamiaceae ...
