Yazar "Turan, Gülhan" için listeleme
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5-acetylindan aryloxyacetohydrazone derivatives: Synthesis and antituberculosis activity
Turan, Gülhan; Kaplancıklı, Zafer Asım (1998)Some 5-acetylindan aryloxyacetohydrazone derivatives were synthesized by reacting 5-acetylindan with aryloxyacetohidrazide derivatives in butanol. The structure of the compounds obtained were performed by using IR, 1H NMR, ... -
Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives
Turan, Gülhan; Yurttaş, Leyla; Saka, Güner; Cantürk, Zerrin; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Natural Products Inc, 2016)The synthesis of nine new quinazoline derivatives (2a-21) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine ... -
Bazı 1-[(N,N-disübstitüetiyokarbonil-tiyo)asetil]-3-(2-tiyenil)-5-aril-2-pirazolin türevlerinin sentezleri ve antifungal, antibakteriyel etkilerinin araştırılması
Özdemir, Ahmet, 1972- (Anadolu Üniversitesi, 2004)Ditiyokarbamat türevlerinin önemli antifungal ve antibakteriyel aktivitelere sahip oldukları literatür araştırmalarında gözlenmiştir. Pirazolin türevIerinin de antifungal ve antibakteriyel aktivite gösterdikleri bilinmektedir. ... -
Bazı 4-fenil/siklohegzil-5-(1-fenoksietil)-2,4-dihidro-3H-1,2,4-triazol-3-tiyon türevlerinin sentezleri ve antifungal, antibakteriyel aktivitelerinin araştırılması
Kaplancıklı, Zafer Asım (Anadolu Üniversitesi, 2003)Hedeflenen maddelere ulaşabilmek ıçın üç farklı 2-kloro-N-(2- tiyazolil)asetamid türevi ve ikisi literatürde kayıtlı olmayan beş farklı 4- Fenil/siklohegzil-5-(1 -fenoksietil)-2,4-dihidro-3H -1, 2,4-triazol-3-tiyon türevinden ... -
Bazı İmidazo[1,2-a]pirazin Türevlerinin Sentezi ve Antinosiseptif Aktivitelerinin Değerlendirilmeleri
Amaç: İmidazopirazin halkası biyolojik olarak aktif bir heterosiklik halkadır. Bir dizi hidrazid-hidrazon türevi bileşiğin antibakteryial-antifungal, antikonvülzan, antiinflamatuvar, antitüberkülotik ve analjezik aktiviteye ... -
Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
Kaya, Betül; Hussin, Weiam; Yurttaş, Leyla; Turan, Gülhan; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Georg Thieme Verlag Kg, 2017)Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ... -
Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
Turan, Gülhan; Hussein, Weiam; Sağlık, Begüm Nurpelin; Tabbi, Aouatef; Korkut, Büşra (MDPI, 2018)A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The ... -
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Turan, Gülhan; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the current work, new 1,3,4-oxadiazole derivatives were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines. Compounds ... -
Evaluation of antidepressant-like effect of 2-pyrazoline derivatives
Gök, Şule; Demet, M. Murat; Özdemir, Ahmet; Turan, Gülhan (Birkhauser Boston Inc, 2010)Many studies have shown that pyrazoline derivatives have therapeutic potential as antidepressant drugs. In this study, we aimed to investigate the antidepressant-like effect of eight new 1-[(N,N-disubstituted thiocarbamo ... -
Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors
Turan, Gülhan; Hussein, Weiam; Sağlık, Begüm Nurpelin; Baysal, Merve; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language ability and other cognitive deterioration, ... -
N-(chroman-4-ylidene)aryloxyacetohydrazones: Synthesis and antimicrobial activity
In this study, some N-(chroman-4-ylidene)phenoxyacetohydrazone and N-(chroman-4-ylidene)phenoxypropiohydrazone compounds were synthesized. Structure of the compounds were identified by using IR, 1H NMR and MASS spectral ... -
New pyrazoline derivatives and their antidepressant activity
Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Altıntop, Mehlika Dilek; Can, Özgür Devrim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental ... -
New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation
Turan, Gülhan; Yurttaş, Leyla; Tabbi, Aouatef; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Kaplancıklı, Zafer Asım (MDPI AG, 2018)In this study, novel N-(3-cyclohexyl/phenyl-4-(substituted phenyl)thiazole-2(3H)-ylidene)-2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetohydrazide (4a-4k) derivatives were synthesized and their anticancer potency were ... -
New triazole and triazolothiadiazine derivatives as possible antimicrobial agents
Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; Revıal, Gilbert (Elsevier France-Editions Scientifiques Medicales Elsevier, 2008)Triazole and triazoles fused with six-membered ring systems are found to possess diverse applications in the fields of medicine, agriculture and industry. The new 1,2,4-triazole and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine ... -
Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation
Özdemir, Ahmet; Turan, Gülhan; Kaplancıklı, Zafer Asım (Scientific Technical Research Council Turkey-Tubitak, 2008)Fourteen new 1-[(N, N-disubstitutedthiocarbamoylthio) acetyl]-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines and appropriate sodium salts of ... -
Novel Naphthyridine-Hydrazone Derivatives and their Antimicrobial Activity
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Demirci, Fatih; Mohsen, Abu Usama; Kaplancıklı, Zafer Asım (2014)Amaç: Bu çalışmada, on yeni Naftiridin-Hidrazon türevinin sentezi ve antimikrobiyal aktivitelerinin değerlendirilmesi amaçlanmıştır. Materyal ve Metod: Sentezlenen bileşiklerin yapıları 1H-NMR ve MS spectral verileri ile ... -
A novel series of thiazolyl-pyrazoline derivatives: Synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirel, Rasime; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the current work, new thiazolyl pyrazoline derivatives (1-22) were synthesized and evaluated for their antifungal effects against pathogenic yeasts and molds using a broth microdilution assay. Ames assay was carried out ... -
Preparation of some pyrazoline derivatives and evaluation of their antifungal activities
Özdemir, Ahmet; Turan, Gülhan; Kaplancıklı, Zafer Asım; Revıal, Gilbert; Demirci, Fatih; İşcan, Gökalp (Informa Healthcare, 2010)The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. ... -
Preparation of Some Thiazolyl Hydrazone Derivatives and Evaluation of Their Antibacterial Activities
Turan, Gülhan; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Fehrentz, Jean-Alain; Martinez, Jean; Chevallet, Pierre; Dusart, Gislaine (Taylor & Francis LTD, 2009)The increasing clinical importance of drug-resistant fungal and bacterial pathogens has provided additional urgency to microbiological research and to the development of new antibacterial compounds. For this purpose, new ...
