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Multifunctional quinoxaline-hydrazone derivatives with acetylcholinesterase and monoamine oxidases inhibitory activities as potential agents against Alzheimer's disease
Cevik, Ulviye Acar; Osmaniye, Derya; Saglik, Begum Nurpelin; Cavusoglu, Betul Kaya; Levent, Serkan; Karaduman, Abdullah Burak; Turan, Gulhan (Springer Birkhauser, 2020)Multitarget molecules are considered as an effective way for the treatment of AD, instead of the classic one-drug-one-target strategy because of the multifactorial nature of AD. A variety of studies indicate that several ... -
Synthesis and monoamine oxidase A/B inhibitory evaluation of new benzothiazole-thiazolylhydrazine derivatives
Turan, Gulhan; Osmaniye, Derya; Saglik, Begum Nurpelin; Cevik, Ulviye Acar; Levent, Serkan; Cavusoglu, Betul Kaya; Kaplancikli, Zafer Asim (Taylor & Francis Ltd, 2020)In this study, a novel series of benzothiazole-thiazolylhydrazine (3a-3i) was synthesized and their structures were characterized by H-1-NMR, C-13-NMR spectrometry, and mass spectroscopy. These compounds were evaluated as ... -
Synthesis of new benzothiazole derivatives bearing thiadiazole as monoamine oxidase inhibitors
Acar Cevik, Ulviye; Osmaniye, Derya; Saglik, Begum N.; Levent, Serkan; K. Cavusoglu, Betul; Karaduman, Abdullah B.; Turan, Gulhan (Wiley, 2020)Monoamine oxidases (MAO) are enzymes that catalyze the oxidative deamination of monoamines such as dopamine, noradrenaline, adrenaline, and serotonin. Recent studies have shown that numerous benzothiazole derivatives exhibit ...
