Yazar "Turan, Nazlı" için listeleme
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1,3,5-triaril-4,5-dihidro-1h-pirazol türevi bazı bileşiklerin benzodiazepin reseptörleri aracılıklı anksiyolitik-benzeri etkileri
Can, Özgür Devrim; Turan, Nazlı; Alyu, Feyza (2016)Amaç: Pirazol, üç karbon atomundan ve yan yana iki azot atomundan oluşan beş üyeli heterosiklik bir halka sistemidir. Literatürde pirazol çekirdeği taşıyan kimyasal bileşiklerin santral sinir sistemi üzerinde önemli bir ... -
Antidepressant-like effect of gallic acid in mice: Dual involvement of serotonergic and catecholaminergic systems
Can, Özgür Devrim; Turan, Nazlı; Özkay, Ümide Demir; Öztürk, Yusuf (Pergamon-Elsevier Science LTD, 2017)Aims: This study was planned to examine the antidepressant potency of gallic acid (30 and 60 mg/kg), a phenolic acid widely distributed in nature, together with its possible underlying monoaminergic mechanisms. Main methods: ... -
Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways
Can, Özgür Devrim; Alyu, Feyza; Turan, Nazlı; Özdemir, Ahmet (Bentham Science Publ LTD, 2016)This study was planned to investigate possible antinociceptive activity of 1,5-diaryl-3-[4-(methylsulfonyl) phenyl]-4,5-dihydro-1H-pyrazole derivatives (2a-s), based on the analgesia-inducing potential of 4,5-dihydro-1H-pyrazole ... -
A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats
Özkay, Ümide Demir; Can, Özgür Devrim; Sağlık, Begüm Nurpelin; Turan, Nazlı (Polish Acad Sciences Inst Pharmacology, 2017)Background: Acetylcholinesterase (AChE) inhibitors are frequently prescribed to mitigate the cognitive decline in Alzheimer's disease. Thus, we investigated the possible efficacy of the AChE inhibitor 2-[(6-Nitro-2-benzothiazolyl) ... -
Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms
Aydın, Taliha H.; Can, Özgür Devrim; Özkay, Ümide Demir; Turan, Nazlı (Wiley, 2016)In this study, we investigated the effects of subacute agomelatine (40 and 80 mg/kg) administration on chronic hyperglycemia, metabolic parameters, and pain perception in streptozotocin-induced diabetic rats. Fasting blood ... -
Investigating the Antidepressant-like Effects of some Benzimidazolepiperidine Derivatives by In-Vivo Experimental Methods
Turan, Nazlı; Özkay, Ümide Demir; Can, Nafiz Öncü; Can, Özgür Devrim (Bentham Science Publ LTD, 2019)Background: Benzimidazole and piperidine rings are important pharmacophore groups for drug design studies. Objective: In this study, we aimed to investigate the antidepressant-like activity of some 2-(4- substituted-phen ... -
Synthesis and antinociceptive activities of some novel benzimidazole-piperidine derivatives
Özkay, Ümide Demir; Can, Özgür Devrim; Turan, Nazlı; Kaya Çavuşoğlu, Betül (Scientific Technical Research Council Turkey-Tubitak, 2017)In this study, a series of benzimidazole-piperidine derivatives were synthesized with the objective of developing potent antinociceptive agents. Some 2-(4-substituted-phenyl) 1 [2 (piperidin-1-yBethyl]-1 H-benzimidazole ...
