Yazar "Uyar, Ruhi" için listeleme
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Benzen ve hidrokinonun megakaryositopoez ve trombositopoeze etkileri
Aydın, Yasemin (Anadolu Üniversitesi, 1989)Benzen ideal bir eritici olması nedeniyle sanayide çok fazla kullanılmaktadır. Yaklaşık yüzyıldır hemopoietik sistem üzerindeki toksit etkileri bilinen benzen ve metabolitlerinin, megakaryositopoez ve trombositler üzerine ... -
Ceranib-2 induces apoptosis in prostate cancer cells
Kuş, Gökhan; Kabadere, Selda; Kutlu, Hatice Mehtap; Uyar, Ruhi (Wiley-Blackwell, 2015)… -
Ceranib-2 inhibits the proliferation and induces apoptosis of glioma cells in vitro
Kabadere, Selda; Kuş, Gökhan; Öztopçu-Vatan, Pınar; Uyar, Ruhi (Wiley-Blackwell, 2015)… -
Comparing the Role of Silymarin on Survival Rate of Rat Glioma With Primary Mixed Rat Glia Cells in Vitro
Gezgin, Duygu; Kabadere, Selda; Uyar, Ruhi; Kuş, Gökhan (Parlar Scientific Publications (PSP), 2013)Phytochemicals, nutraceuticals and herbal products, such as silymarin, have gained ever growing popularity and are valued for their ability to defend against almost all types of disease. Primarily known as hepatoprotective ... -
Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells
Kuş, Gökhan; Özkurt, Mete; Öztopçu Vatan, Pınar; Erkasap, Nilüfer; Uyar, Ruhi; Kabadere, Selda (Tubitak Scientific & Technical Research Council Turkey, 2018)Inhibiting ceramidase activity in cancer cells has been identified as a promising target for cancer therapy in recent studies. Thus, we examined the possible role of ceranib-2, a novel ceramidase inhibitor, on growth and ... -
Cytotoxic and apoptotic effects of ceranib-2 offering potential for a new antineoplastic agent in the treatment of cancer cells
Vejselova, Djanan; Kutlu, Hatice Mehtap; Kuş, Gökhan; Kabadere, Selda; Uyar, Ruhi (Tubitak Scientific & Technical Research Council Turkey, 2014)Fibrocarcinomas are malignant tumours that originate in mesenchymal cells. The tumours typically form in the presence of connective tissue and are of key consideration when assessing research priorities for future healthcare ... -
Cytotoxic and Apoptotic Functions of Licofelone on Rat Glioma Cells
Kuş, Gökhan; Öztopçu-Vatan, Pınar; Uyar, Ruhi; Kabadere, Selda (Akademiai Kiado Zrt, 2013)Gliomas are the largest group of central nervous system tumors and despite of clinical treatments death rate is very high. Inhibition of both cyclooxygenase and lipoxygenase pathways that take role in arachidonic acid ... -
Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2
Kuş, Gökhan; Kabadere, Selda; Uyar, Ruhi; Kutlu, Hatice Mehtap (Springer, 2015)Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential ... -
Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis
Kabadere, Selda; Kuş, Gökhan; Uyar, Ruhi; Öztopçu-Vatan, Pınar (Informa Healthcare, 2014)Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways ... -
Licofelone Inhibits Proliferation of Rat Hepatoma Cells
Öztopçu-Vatan, Pınar; Kuş, Gökhan; Man, Emine; Korkut, Melek Gunindi; Kabadere, Seida; Uyar, Ruhi (Zoological Soc Pakistan, 2017)Despite clinical treatments, hepatocellular carcinoma is one of the most common causes of cancer death. We tested whether licofelone, an inhibitor of both cyclooxygenase and lipoxygenase pathways of arachidonic acid ...
