Yazar "Varol, Mehmet" için listeleme
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Anti-breast cancer activities of some secondary metabolites isolated from lichen species
Varol, Mehmet; Candan, Mehmet (Wiley-Blackwell, 2016)… -
Anti-breast cancer and anti-angiogenic potential of a lichen-derived small-molecule: barbatolic acid
Varol, Mehmet (Springer, 2018)Natural products have been used for centuries as the most potent remedies to cure many diseases including cancer diseases. Angiogenesis is defined as the formation of new capillaries from existing vessels and plays a key ... -
Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes
Varol, Mehmet; Koparal, Ayşe Tansu; Benkli, Kadriye; Bostancıoğlu, Rakibe Beklem (Bentham Science Publ LTD, 2018)Background: Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the long-term side effects. Objective: A ... -
Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp siculum
Rosselli, Sergio; Bruno, Maurizio; Raimondo, Francesco Maria; Spadaro, Vivienne; Varol, Mehmet; Koparal, Ayşe Tansu; Maggio, Antonella (MDPI, 2012)A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been ... -
Darwinian principles toward multidrug-resistant cancer cells
Varol, Mehmet (Arslan Intellectual Works, 2016)[No abstract available] -
Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents
Varol, Mehmet; Benkli, Kadriye; Koparal, Ayşe Tansu; Bostancıoğlu, Rakibe Beklem (Taylor & Francis LTD, 2019)Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. ... -
Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones
Çağır, Ali; Odaci, Burcu; Varol, Mehmet; Akcok, İsmail; Okur, Özgür; Koparal, Ayşe Tansu (Bentham Science Publ LTD, 2017)Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel ... -
Evaluation of the sunscreen lichen substances usnic acid and atranorin
Varol, Mehmet; Tay, Turgay; Candan, Mehmet; Türk, Ayşen Özdemir; Koparal, Ayşe Tansu (Inst Histol Embriol-Conicet, 2015)Usnic acid and atranorin are known as both sunscreen substances in natural lichen population and cytotoxic substances on human cell lines. Both substances were isolated from the acetone extracts of Cladonia foliacea and ... -
Küçük molekül yapılı doğal bileşiklerin tümör gelişimi ve yayılımında yeni damar oluşumu hedefli tedavi potansiyellerinin epigenetik yaklaşım ve moleküler mekanizmalarla incelenmesi
Varol, Mehmet (Anadolu Üniversitesi, 2017)Likenler; mantar ve alglerin birliktelikleri sonucu oluşmuş simbiyotik ortaklıklardır ve bu birliktelik içinde kurulan ileri seviyeli metabolik ilişki sayesinde, 1000'den fazla özgün liken bileşiği sentezlenmektedir. Liken ... -
Liken asitlerinin ultraviyole ışınlara karşı koruyucu etkisinin incelenmesi
Varol, Mehmet (Anadolu Üniversitesi, 2013)Yaşadığımız çağın en büyük problemlerinden biri ozon tabakasındaki delinme sonucu artan deri kanseri vakaları gibi gözükmektedir. Deri kanseri açık tenli popülasyonlarda en sık rastlanan kanser tipidir. Bu nedenle, UV-B ... -
Parietin as an efficient and promising anti-angiogenic and apoptotic small-molecule from Xanthoria parietina
Varol, Mehmet (Soc Brasileira Farmacognosia, 2019)Lichens that are exclusive symbiotic organisms composed of fungus and alga, are considered as a wealthy source of biologically and pharmacologically active small-molecules thanks to the tight metabolic relationship between ... -
Photoprotective Activity of Vulpinic and Gyrophoric Acids Toward Ultraviolet B-Induced Damage in Human Keratinocytes
Varol, Mehmet; Türk, Ayşen Özdemir; Candan, Mehmet; Tay, Turgay; Koparal, Ayşe Tansu (Wiley, 2016)Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations because of their chemical structures. However, to the best of our knowledge, there has been no reference to their cosmetic ...
