Yazar "Yıldırım, Şafak Ulusoylar" için listeleme
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Apoptotic effects of some carbazole derivatives on lung carcinoma and glioma cell lines
Çiftçi, Gülsen Akalın; Temel, Halide Edip; Yıldırım, Şafak Ulusoylar; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Genç, Lütfi (Springer Birkhauser, 2013)In this study, we aimed to study the apoptotic effects of 2-[(9-ethyl-9H-carbazol-3-yl)amino]-2-oxoethyl N,N-disubstituted dithiocarbamates on A549 lung carcinoma and C6 glioma cell lines. Cytotoxicity analyses of DNA ... -
Induction of apoptosis in lung adenocarcinoma and glioma cells by some oxadiazole derivatives
Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım (Springer Birkhauser, 2014)Oxadiazoles have received much attention due to their wide range of biological activities including antitumor activity. In this study, we aimed to study apoptotic effects of some 1,3,4-oxadiazole derivatives on human lung ... -
The LC/ESI-MSMS Profiles and Biological Potentials of Vitex agnus castus Extracts
Ağalar, Hale Gamze; Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar; Göğer, Fatih; Kırımer, Neşe (Natural Products Inc, 2016)The chemical profile, cytotoxic and apoptotic effect, and antioxidant activity were determined of ethanolic extracts of Vitex agnus-castus L. (chaste tree). Ripened fruits and fruitless aerial parts were extracted with ... -
Synthesis and anticandidal activity of new triazolothiadiazine derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; İşcan, Gökalp; Akalın Çiftçi, Gülsen; Yıldırım, Şafak Ulusoylar (Elsevier France-Editions Scientifiques Medicales Elsevier, 2011)New triazolothiadiazine derivatives were synthesized via the ring closure reaction of 4-amino-5-substituted-2,4-dihydro-3H-1,2,4-triazol-3-thiones with phenacyl bromides. The compounds were tested in vitro against various ... -
Synthesis and antiproliferative activity of new 1,5-disubstituted tetrazoles bearing hydrazone moiety
Kaplancıklı, Zafer Asım; Yurttaş, Leyla; Özdemir, Ahmet; Turan, Gülhan; Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar; Abu Mohsen, Usama (Springer Birkhauser, 2014)A new class of tetrazole-hydrazone derivatives including chloro-substituted phenyl moiety were synthesized to perform anticancer activity screening. The structural elucidation of the compounds was performed by IR, H-1 NMR, ... -
Synthesis and Biological Evaluation of Some 1,2-Disubstituted Benzimidazole Derivatives as New Potential Anticancer Agents
Yurttaş, Leyla; Demirayak, Şeref; Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar; Kaplancıklı, Zafer Asım (Wiley-V C H Verlag GMBH, 2013)The synthesis of some new 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives and investigation of their anticancer activities were the aims of this work. 2-(Chloromethyl)benzimidazole compound ... -
Synthesis of 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and evaluation of their anticancer activity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar (Informa Healthcare, 2013)In the present study, 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives (1-6) were synthesized via the ring closure reaction of 1-(2-thienyl)-3-aryl-2-propen-1-ones with hydrazine hydrate in acetic acid. The chemical ... -
Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains
Yurttaş, Leyla; Özkay, Yusuf; Demirci, Fatih; Göğer, Gamze; Yıldırım, Şafak Ulusoylar; Abu Mohsen, Usama; Kaplancıklı, Zafer Asım (Scientific Technical Research Council Turkey-Tubitak, 2014)Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a-j) were confirmed by ...
