Yazar "Özkay, Yusuf" için WoS İndeksli Yayınlar Koleksiyonu listeleme
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New 1,4-dihydro[1,8]naphthyridine derivatives as DNA gyrase inhibitors
Karaca Gencer, Hülya; Levent, Serkan; Çevik, Ulviye Acar; Özkay, Yusuf; Ilgın, Sinem (Pergamon-Elsevier Science LTD, 2017)Owing to the growing need for novel antibacterial agents, we synthesized a novel series of fluoroquinolones including 7-substituted-1-(2,4-difluoropheny1)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ... -
New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation
Karaca Gencer, Hülya; Çevik, Ulviye Acar; Levent, Serkan; Sağlık, Begüm Nurpelin; Korkut, Büşra; Özkay, Yusuf; Öztürk, Yusuf (MDPI AG, 2017)Owing to the growing need for antifungal agents, we synthesized a new series 2-((5-(4-(5-substituted-1H-benzimidazol-2-yl)phenyl)-4-substituted-4H-1,2,4-triazol-3-yl)thio)-1-(substituted phenyl)ethan-1-one derivatives, ... -
Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
Kaya, Betül; Yurttaş, Leyla; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2017)In the present study, a new series of 2-[4-(pyrimidin-2-yl) piperazin-1-yl]-2-oxoethyl 4-substituted piperazine- 1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory ... -
Novel imidazole derivatives as antifungal agents: Synthesis, biological evaluation, ADME prediction and molecular docking studies
Altındağ, Firuze Diyar; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Işıkdağ, İlhan; Özkay, Yusuf; Karaca Gencer, Hülya (Taylor & Francis LTD, 2019)A series of 2-(substituteddithiocarbamoyl)-N-[4-((1H-imidazol-1-yl)methyl)phenyl]acetamide derivatives was designed and synthesized to combat the increasing incidence of drug-resistant fungal infections. All synthesized ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
Osmaniye, Derya; Sağlık, Begüm Nurpelin; Acar Çevik, Ulviye; Levent, Serkan; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Turan, Gülhan (MDPI, 2019)Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life ... -
Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Levent, Serkan; Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2019)Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly ... -
Synthesis and analgesic effects of 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives
Özkay, Ümide Demir; Özkay, Yusuf; Can, Özgür Devrim (Springer Birkhauser, 2011)This present study was undertaken to synthesize and investigate possible analgesic activities of some 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives that were designed by combining an analgesic ... -
Synthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives containing (benz)azole moiety
Yurttaş, Leyla; Özkay, Yusuf; Akalın-Çiftçi, Gülsen; Ulusoylar-Yıldırım, Şafak (Informa Healthcare, 2014)A new class of novel thiazole-(benz) azole derivatives was synthesized to investigate their anticancer activity. The structure of the compounds was confirmed by IR, H-1-NMR, and MS spectral data and elemental analyses. ... -
Synthesis and anticancer activity of some novel benzothiazole-thiazolidine derivatives
Osmaniye, Derya; Levent, Serkan; Ardıç, Cankiz Mina; Atlı Eklioğlu, Özlem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2018)Sixteen new 2-(benzothiazol-2-ylthio)-N-(3-substituted-4-(3,4-substitutedphenyl)thiazol-2(3H)-ylidene)acetohydrazide derivatives (4a-4p) were synthesized. The structures of the synthesized compounds were elucidated using ... -
Synthesis and antimicrobial activity evaluation of new dithiocarbamate derivatives bearing thiazole/benzothiazole rings
Yurttaş, Leyla; Özkay, Yusuf; Duran, Murat; Turan, Gülhan; Özdemir, Ahmet; Cantürk, Zerrin; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)The synthesis of 2-(substituted phenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A1-A24) derivatives and 2-(4-substituted thiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B1-B14) ... -
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives
Yurttaş, Leyla; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Tunalı, Yağmur; Karaca Gencer, Hülya (Taylor & Francis LTD, 2013)In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and ... -
Synthesis and Antimicrobial Activity of Some Novel Benzimidazole Hydrazides
Özkay, Yusuf; Tunalı, Yağmur; Karaca, H.; Işıkdağ, İlhan (Asian Journal Of Chemistry, 2011)The present study was undertaken to synthesize some 4-(5,6-dichloro-1H-benzimidazole-2-yl)phenoxyacetic acid-4-substituted benzylidene hydrazide derivatives and investigate their possible antimicrobial activity. Chemical ... -
Synthesis and Antimicrobial Evaluation of Some 2,5-Disubstituted Benzimidazole Derivatives
Yurttaş, Leyla; Özkay, Yusuf; Karaca, Hülya; Tunalı, Yağmur; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2013)Some benzimidazole derivatives bearing hydrazone moiety were synthesized and their in vitro antimicrobial activity was determined against various gram-positive and gram-negative bacteria, and fungi using microbroth dilution ... -
Synthesis and antiproliferative activity evaluation of new thiazole-benzimidazole derivatives using real-time cell analysis (RTCA DP)
Özkay, Yusuf; Yurttaş, Leyla; Dikmen, Miriş; EnGür, Selin (Springer Birkhauser, 2016)A series of new 2-[(5-substituted-1H-benzimidazol-2-yl)thio]-N-[4-[2-phenylthiazol-4-yl]phenyl]acetamide derivatives (4a-p) were synthesized according to the reported literature, and anticancer activity of the compounds ... -
Synthesis and Biological Evaluation of a Series of Dithiocarbamates as New Cholinesterase Inhibitors
Altıntop, Mehlika Dilek; Gürkan-Alp, A. Selen; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Wiley-V C H Verlag GMBH, 2013)In the present paper, a novel series of dithiocarbamates was synthesized via the treatment of 4-(trifluoromethyl)benzyl chloride with appropriate sodium salts of N,N-disubstituted dithiocarbamic acids. H-1 NMR, mass spectral ... -
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease
Hussein, Weiam; Sağlık, Begüm Nurpelin; Levent, Serkan; Korkut, Büsra; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the ... -
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
Tok, Fatih; Koçyiğit-Kaymakçıoğlu, Bedia; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Academic Press Inc Elsevier Science, 2019)In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, H-1 NMR, C-13 NMR and mass spectroscopies. The inhibitory potency of ... -
Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives
Kaya, Betül; Özkay, Yusuf; Temel, Halide Edip; Kaplancıklı, Zafer Asım (Hindawi LTD, 2016)Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N'-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide ... -
Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents
Abu Mohsen, Usama; Yurttaş, Leyla; Acar, U.; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Karaca Gencer, Hülya; Cantürk, Zerrin (Georg Thieme Verlag Kg, 2015)In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]- ...