Yazar "Özkay, Yusuf" için WoS İndeksli Yayınlar Koleksiyonu listeleme
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Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors
Tugrak, Mehtap; Gül, Halise İnci; Bandow, Kenjiro; Sakagami, Hiroshi; Gülçin, İlhami; Özkay, Yusuf; Supuran, Claudiu T. (Academic Press Inc Elsevier Science, 2019)New mono Mannich bases, (2-(4-hydroxy-3-((4-substituephenylpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-one), were prepared to evaluate their cytotoxic/anticancer properties and also their inhibitory effects ... -
Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives
Sağlık, Begüm Nurpelin; Özkay, Yusuf; Özkay, Ümide Demir; Karaca Gencer, Hülya (Hindawi LTD, 2014)18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity. Structures of the synthesized compounds were elucidated by ... -
Synthesis and Evaluation of Anti-acetylcholinesterase Activity of Some Benzothiazole Based New Piperazine-dithiocarbamate Derivatives
Mohsen, U. A.; Kaplancıklı, Zafer Asım; Özkay, Yusuf; Yurttaş, Leyla (Georg Thieme Verlag Kg, 2015)In this present study some benzothiazole derivatives bearing piperazine and thiocarbamate moieties were synthesized and their potential anticholinesterase properties were investigated. A set of 30 new compounds of ... -
Synthesis and Evaluation of Heterocycles Based Chalcone Derivatives as Anti-proliferative Agents
Kaya Çavuşoğlu, Betül; Atlı Eklioğlu, Özlem; Gormus, Geozde; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background: The lack of selectivity and development of drug-resistance encourage researchers to search for novel, more efficient and multi-targeted agents with less toxicity. Objective: In this paper, a series of novel ... -
Synthesis and Evaluation of N-[1-(((3,4-Diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs
Turan, Gülhan; Tabbi, Aouatef; Hussein, Weiam; Karaduman, Abdullah Burak; Sağlık, Begüm Nurpelin; Özkay, Yusuf (Hindawi LTD, 2018)A series of N-[1-(((3,4-diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide derivatives (4a-4i) were synthesized in good yield and assayed for their inhibitory potency against monoamine oxidase (MAO) isoforms. ... -
Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Ardıç, Cankiz Mina; Özkay, Yusuf; Atlı Eklioğlu, Özlem (Walter De Gruyter GMBH, 2018)Objectives: Cancer is one of the leading causes of death throughout the world. Current therapy options suffer from the major limitations of side effects and drug resistance. Thus, continuing search for newer and safer ... -
Synthesis and Evaluation of New Dithiocarbamic Acid 6,11-Dioxo-6,11-dihydro-1H-anthra[1,2-d]-imidazol-2-yl Methyl Esters
Önder, Nur İpek; Seller, Zerrin; Özkay, Yusuf (Wiley-V C H Verlag GMBH, 2015)A novel series of dithiocarbamic acid 6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl methyl esters were synthesized and their cytotoxic and apoptotic activities were evaluated on HeLa cells. Some of these compounds ... -
Synthesis and MAO inhibitory activity of novel thiazole-hydrazones
Atlı Eklioğlu, Özlem; Özkay, Yusuf (Scientific Technical Research Council Turkey-Tubitak, 2017)A series of new thiazole-hydrazones (3a-3n) were synthesized, characterized, and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method. Selectivity indexes (SIs) were expressed as IC50 ... -
Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl]acetamide derivatives and evaluation of their anticancer activity
Özkay, Yusuf; Işıkdağ, İlhan; Seller, Zerrin; Akalın Çiftçi, Gülsen (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In the present study 18 novel imidazole-(benz)azole and imidazole-piperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR, ... -
Synthesis of new 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluation of their antidepressant-like effects
Özkay, Ümide Demir; Yurttaş, Leyla; Özkay, Yusuf; Ucel, Umut İrfan; Can, Özgür Devrim; Öztürk, Yusuf (Pharmaceutical Soc Korea, 2013)In this study, we synthesized eight novel 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluated their antidepressant-like activities. The chemical structures of the synthesised compounds were elucidated ... -
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
Osmaniye, Derya; Levent, Serkan; Karaduman, Abdullah Burak; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at ... -
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes
Sağlık, Begüm Nurpelin; Ilgın, Sinem; Özkay, Yusuf (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP analogues were synthesized. Structures of the synthesized ... -
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Cantürk, Zerrin; Bueno, Juan; Demirci, Fatih; Koparal, Ali Savaş (Bentham Science Publ LTD, 2017)In the present study, nineteen new fluoro-benzimidazole derivatives, including nifuroxazide analogs, were synthesized by microwave-supported reactions and tested against a panel of pathogenic microorganisms consisting of ... -
Synthesis of new piperazine compounds and investigation of their anticholinesterase effects
Özkay, Yusuf (Çukurova University, Fac Medicine, 2017)Purpose: The aim of present study is to evaluate anticholinesterase activities of some new piperazine compounds. Materials and Methods: Ten new piperazine derivatives were synthesized. Structure elucidation of the synthesized ... -
Synthesis of Novel 4-(Dimethylaminoalkyl) piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors
Çevik, Ulviye Acar; Levent, Serkan; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Carbamate compounds have attracted a great deal of interest in medicinal chemistry due to their inhibition potential against cholinesterase enzymes. Method: Hence, this study was undertaken to synthesize new ... -
Synthesis of Some Benzothiazole Based Piperazine-Dithiocarbamate Derivatives and Evaluation of Their Anticancer Activities
Turan, Gülhan; Özkay, Yusuf; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek (Bentham Science Publ LTD, 2011)Some benzothiazole derivatives bearing piperazine and dithiocarbamate moieties were synthesized in order to investigate their anticancer activity. The structures of the obtained compounds were confirmed by spectral data ... -
Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation
Yurttaş, Leyla; Özkay, Yusuf; Karaca Gencer, Hülya; Acar, Ulviye (Hindawi LTD, 2015)New 2-(4-arylpiperazine-1-yl)-N-[4-(2-(4-substituted phenyl)thiazol-4-yl)phenyl]acetamide derivatives were synthesized and evaluated for their antimicrobial and anticholinesterase activities. Acetylcholinesterase inhibitory ... -
Synthesis of some novel 2-substituted benzothiazole derivatives containing benzylamine moiety as monoamine oxidase inhibitory agents
Kaya, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)In the present work, 12 new 2-(5-substituted-benzothiazol-2-ylsulfanyl)-N-(substitutedbenzyl)-N-(4-substitutedphenyl) acetamide derivatives (4a-l) was designed and synthesized. The structures of the synthesized compounds ... -
Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains
Yurttaş, Leyla; Özkay, Yusuf; Demirci, Fatih; Göğer, Gamze; Yıldırım, Şafak Ulusoylar; Abu Mohsen, Usama; Kaplancıklı, Zafer Asım (Scientific Technical Research Council Turkey-Tubitak, 2014)Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a-j) were confirmed by ... -
Synthesis, Characterization, and Molecular Docking Study of Some Novel Imidazole Derivatives as Potential Antifungal Agents
Işık, Ayşen; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf (Wiley, 2019)The azole pharmacophore is still regarded as a viable lead structure for the synthesis of more effective antifungal agents. In this study, two novel series of imidazole derivatives containing dithiocarbamate (5a-5g) and ...