Analitik Kimya Anabilim Dalı by Institution Author "Can, Nafiz Öncü"
Now showing items 1-20 of 22
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Analysis of Acrylamide in Traditional and Nontraditional Foods in Turkey Using Hplc-Dad With Spe Cleanup
Can, Nafiz Öncü; Arli, Göksel (Taylor & Francis Inc, 2014)Acrylamide is a heat-generated food toxicant, which exists in various foodstuffs such as potato chips, biscuits, and coffee. It has been demonstrated that acrylamide possesses some neurotoxic and carcinogenic effects and ... -
Comparative study of different chemistries and particle properties, high-performance liquid chromatography stationary phases in separation of escitalopram oxalate and its impurities in different pharmaceutical dosage forms
Badulla, Wafa; Can, Nafiz Öncü; Atkoşar, Zeki; Arli, Göksel; Aboul-Enein, Hassan Y. (Wiley-V C H Verlag GMBH, 2019)The liquid chromatographic separation performance of 12 different columns was evaluated for the estimation of the escitalopram oxalate and six of its impurities in different pharmaceutical formulations. All columns exhibited ... -
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors
Can, Nafiz Öncü; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; Korkut, Büşra; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the recent works, it was shown that numerous thiazolylhydrazine derivatives display hMAO inhibitory activity in the range of micromolar concentration. Hence, in the present study a new series of new thiazole-hydrazines ... -
Determination of amoxicillin by flow injection analysis using UV-detection, potentiometry, and conductometry in pharmaceutical preparations
Altıokka, Göksel; Can, Nafiz Öncü; Aboul-Enein, Hassan Y. (Taylor & Francis Inc, 2007)A method for direct determination of amoxicillin in pharmaceuticals using flow injection analysis (FIA) with UV detection adjusted at 228 nm, along with potentiometer and condoptometric methods are described. The best ... -
Determination of azapropazone in its pharmaceutical form by HPLC and flow injection analysis
Can, Nafiz Öncü; Altıokka, Göksel (Taylor & Francis Inc, 2005)Azapropazone is an analgesic and anti-inflammatory agent that is used in the treatment of musculoskeletal and joint disorders, as well as in acute gout, because of its uricosuric properties. A simple and sensitive high ... -
Determination of cefuroxime axetil in tablets and biological fluids using liquid chromatography and flow injection analysis
Can, Nafiz Öncü; Altıokka, Göksel; Aboul-Enein, Hassan Y. (Elsevier Science BV, 2006)Cefuroxime axetil is the pro-drug of cephalosporin cefuroxime that is used in the treatment of common community-acquired infections. A simple and precise liquid chromatographic method for the determination of cefuroxime ... -
The determination of levofloxacin by flow injection analysis using UV detection, potentiometry, and conductometry in pharmaceutical preparations
Altıokka, Göksel; Atkoşar, Zeki; Can, Nafiz Öncü (Pergamon-Elsevier Science LTD, 2002)A flow injection analysis (FIA) using UV detection, potentiometry and conductometry for levofloxacin (LVF) are described in this study. The best solvent system was found to consist of 0.2 V acetate buffer at pH 3 having ... -
Determination of nabumetone in pharmaceutical formulation by flow injection analysis (FIA) with UV-detection
Can, Nafiz Öncü; Tuncel, M; Aboul-Enein, Hassan Y. (Govi-Verlag GMBH, 2003)A precise and accurate FIA method for the quantification of nabumetone (NAB) in pharmaceuticals is described. The best suitable carrier solvent system consisted of ethanol: water (30: 70 v/v). Sample solution (4.7 x 10(-6) ... -
Determination of Ochratoxin A in Turkish Wines
Altıokka, Göksel; Can, Nafiz Öncü; Atkoşar, Zeki; Aboul-Enein, Hassan Y. (Food & Drug Adminstration, 2009)A validated, simple and highly sensitive analytical method was described for the determination of Ochratoxin A (OTA) in various wines produced in Turkey. OTA concentrations of 25 wine samples were examined using high ... -
Determination of piribedil in human serum, urine and pharmaceutical dosage form by LC-DAD
Altıokka, Göksel; Can, Nafiz Öncü; Aboul-Enein, Hassan Y. (Springer Heidelberg, 2008)A rapid, selective and sensitive reversed-phase liquid chromatographic (LC) method was developed for the determination of piribedil in human serum, urine and pharmaceutical dosage form. LC analysis was carried out using ... -
Determination of Ticlopidine in Pharmaceutical Tablets by Flow Injection Analysis Using UV-Detection
Can, Nafiz Öncü; Altıokka, Göksel; Aboul-Enein, Hassan Y. (Taylor & Francis Inc, 2008)A precise and accurate flow injection analysis method for the quantification of ticlopidine in pharmaceuticals is described. An aqueous carrier stream, which was entirely prepared with water was chosen for the flow injection ... -
Development of Validated and Stability-Indicating LC-DAD and LC-MS/MS Methods for Determination of Avanafil in Pharmaceutical Preparations and Identification of a Novel Degradation Product by LCMS-IT-TOF
Can, Nafiz Öncü (MDPI, 2018)Avanafil (AVA), one of the most effective drugs prescribed for erectile dysfunction, is a pyrimidine-derivative PDE5 inhibitor. In the current work, new LC methods were developed and validated for quantitative determination ... -
HPLC determination of cefprozil in tablets using monolithic and C-18 silica columns
Can, Nafiz Öncü (Wiley-V C H Verlag GMBH, 2011)Cefprozil (CPZ) is a second-generation semi-synthetic cephalosporin antibiotic that commonly exists as the mixture of Z and E diastereoisomers, at the ratio of approximately 9:1. A novel reversed-phase HPLC method for the ... -
A novel dilute and shoot HPLC assay method for quantification of irbesartan and hydrochlorothiazide in combination tablets and urine using second generation C-18-bonded monolithic silica column with double gradient elution
Koyutürk, Sema; Can, Nafiz Öncü; Atkoşar, Zeki; Arli, Göksel (Elsevier Science BV, 2014)Irbesartan (IRB) and hydrochlorothiazide (HCT) are angiotensin-ll receptor antagonist and thiazide-class diuretic compounds, respectively, which are in use in the treatment of hypertension. A novel diluteand-shoot HPLC ... -
A novel RP-HPLC method for simultaneous determination of potassium sorbate and sodium benzoate in soft drinks using C-18-bonded monolithic silica column
Can, Nafiz Öncü; Arli, Göksel; Lafçı, Yiğit (Wiley Periodicals, Inc, 2011)Potassium sorbate and sodium benzoate are food additives that are generally employed for prevention of food spoilage originating from bacteria, molds or yeasts. Although these compounds were generally recognized as safe ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Rapid determination of free anthocyanins in foodstuffs using high performance liquid chromatography
Can, Nafiz Öncü; Arli, Göksel; Atkoşar, Zeki (Elsevier Sci LTD, 2012)Anthocyanins constitute a major group of natural pigments, and they are responsible for the colours of fruits and vegetables. A rapid and feasible assay procedure for the determination of free forms of the six most abundant ... -
Reversed-phase HPLC analysis of levetiracetam in tablets using monolithic and conventional c18 silica column
Can, Nafiz Öncü; Arli, Göksel (2010)Development and validation of an RP-HPLC method for determination of levetiracetam in pharmaceutical tablets is described. The separation and quantification of levetiracetam and caffeine (internal standard) were performed ... -
Reversed-Phase HPLC Analysis of Levetiracetam in Tablets Using Monolithic and Conventional C18 Silica Columns
Can, Nafiz Öncü; Arli, Göksel (Aoac Int, 2010)Development and validation of an RP-HPLC method for determination of levetiracetam in pharmaceutical tablets is described. The separation and quantification of levetiracetam and caffeine (internal standard) were performed ...