Erişim şekli için "info:eu-repo/semantics/openAccess" Biyokimya Anabilim Dalı listeleme
Toplam kayıt 27, listelenen: 1-20
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Akut ve Kronik Sigara İçen Genç Bireylerde Proinflamatuar Durumda HDL Fonksiyonlarının Önemi Nedir?
(2017)Amaç: Sigara içimi, kardiyovasküler hastalıkların en önemli ve önlenebilir risk faktörlerinden biridir. Okside LDL, kardiyovasküler hastalıklarda artış gösterir. Normal yüksek dansiteli lipoprotein (HDL), LDL'yi oksidasyondan ... -
Antioxidant and Antiradical Properties of Selected Flavonoids and Phenolic Compounds
(Hindawi LTD, 2017)Phenolic compounds and flavonoids are known by their antioxidant properties and one of the most important sources for humans is the diet. Due to the harmful effects of synthetic antioxidants such as BHA and BHT, natural ... -
A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells
(Turkish Pharmacists Assoc, 2019)Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt. Materials ... -
Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer
(2020)Thiosemicarbazonesrepresent an important class of ligandsfortargeted therapyof many types of cancer including non-small celllung cancer. In order to identify potential antitumoragentsfor targeted therapy oflung cancer, new ... -
Direct and protective effects of single or combined addition of vincristine and epsilon-viniferin on human HepG2 cellular oxidative stress markers in vitro
(Springer, 2016)The objective of this study is to examine the direct effects of low doses and high doses of epsilon-viniferin, a substance known to be an antioxidant, and vincristine sulphate, a chemotherapeutic agent, alone and in ... -
Effect of alpha lipoic acid and silymarin on bladder outlet obstruction
(Spandidos Publ LTD, 2013)The aim of the present study was to determine whether the treatment of obstructed rat bladders with alpha lipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction ... -
The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats
(Academic Journals, 2012)The objective of this study was to determine the effects of metformin treatment and exercise intervention on lipid metabolism, nitric oxide (NO), nitric oxide synthase (NOS) and glucose levels in streptozotocin-nicotinamide ... -
The effects of atorvastatin on antioxidant/antiinfammatory properties of HDLs in hypercholesterolemics
(2015)Background/aim: Hypercholesterolemia is characterized by changes in lipid profle, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ... -
The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics
(Tubitak Scientific & Technical Research Council Turkey, 2015)Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines
(2011)Fenolik bir monoterpen olan karvakrol kekik bitkisinde bulunmaktadır ve besinlerde baharat olarak kullanılmaktadır. Bu çalışmanın amacı, karvakrol’ün H-ras transform edilmiş 5RP7 ve N-ras transform edilmiş CO25 hücreleri ... -
Effects of sildenafil citrate on survival in the posterior leg replantation model
(Derman Medical Publ, 2017)Aim: Sildenafil citrate is a phosphodiesterase (POE) enzyme inhibitor and a vasodilator agent Its angioprotective and angiogenetic effects are widely known. The aim of this study was to Investigate the effects of sildenafil ... -
The effects of some phenanthroline ruthenium (II) complexes on a549 cell proliferation
(2013)Ruthenium (II) komplekslerinin DNA bağlanması He ilgili olan yüksek antitumor aktiviteleri nedeni He bu bileşikler son yıllarda araştırmacıların yoğun ilgisini çekmektedir. Bu çalismada imidazo[4,5-f][ 1,10]fenantrolin ... -
Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines
(Springer, 2015)Aesculus hippocastanum (the horse chestnut) seed extract has a wide variety of biochemical and pharmacological effects including anti-inflammatory, antianalgesic, and antipyretic activities. The main active compound of ... -
Evaluation of Inhibition Effects of Some Cardiovascular Therapeutics on Human Erythrocyte Carbonic Anhydrase Isoenzymes
(2018)Carbonic anhydrase enzyme plays a vital role in metabolic events such as acid-base regulation and respiration. In our research, it is tried to determine the inhibitory influences of the cardiovascular therapeutics esmolol ... -
H-ras aktif fibroblast hücre apoptozunun bazı 1,3-bis-(heteroaril substitue) benzen türevleri ile uyarılması
(2006)Apoptoz embiryonik gelişim ve doku homeostazın düzenlenmesi esnasında oluşan normal fizyolojik bir olaydır. Günümüzde bazı kemotröpatik ajaların hücre içersinde apoptoz yolaklarını stimüle edebilme yeteneğine sahip olduğu ... -
HepG2 hücrelerinde Vinkristin sülfat/?-viniferin kombinasyonunun vinkristin sülfat ile karşılaştırıldığında artmış etkinliğinin vurgulanması
(2016)Amaç: Bu çalışma HepG2 hücre hattında geç apoptoz ve mitokondriyal yolakta ?-viniferin (?-VNF)'in etkisini incelemek için dizayn edildi. Bu amaç için, HepG2 hücre dizisinde anti-kanser ilaç olarak kullanılan vinkristin ... -
In vitro effects of ethanol and aspirin combined administration on erythrocyte membrane properties
(2009)Bu çalışmanın amacı; etanolün ve etanol ile aspirinin birlikte verilmesinin eritrosit membranındaki in vitro etkilerini açıklamaktır. Bununla birlikte s-adenozilmetiyonin’in (SAMe) muhtemel koruyucu etkisini değerlendirdik ... -
Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study
(Taylor & Francis LTD, 2017)Aldose reductase (AR) inhibitors have vital importance in the treatment and prevention of diabetic complications. In this study, rat kidney AR was purified 19.34-fold with a yield of 3.49% and a specific activity of 0.88 ... -
Koyun Karaciğerinden Alkol Dehidrogenaz: Saflaştırma, Karakterizasyon, ve Bazı Antibiyotiklerin Etkileri
(2017)Alkol dehidrogenaz (ADH), her bir alt biriminin bir Zn2+ metal içeren katalitik alana ve bir kofaktör bağlama alanına sahip olduğu dimerik bir enzimdir. Bu enzim, alkolü, aldehide dönüştürür. Bu makale koyun karaciğerinden ... -
Lipid profle and levels of homocysteine, leptin, fbrinogen and C-reactive protein in hyperthyroid patients before and after treatment
(2010)Amaç: Bu çalışma hipertiroidizmli hastalarda tiroid hormonlarının lipid proflini, eritrosit sedimentasyon hızını (ESR), serum total homosistein (t-hcy), leptin, fbrinojen ve C-reaktif protein (CRP) düzeylerini etkileyip ...