Browsing Makale Koleksiyonu by Title
Now showing items 41-60 of 86
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Evaluation of chalcones as inhibitors of glutathione S-transferase
(Wiley, 2018)Glutathione S-transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play an important role in cellular signaling. In the present study, potential inhibition effects of chalcones were ... -
Evaluation of Inhibition Effects of Some Cardiovascular Therapeutics on Human Erythrocyte Carbonic Anhydrase Isoenzymes
(2018)Carbonic anhydrase enzyme plays a vital role in metabolic events such as acid-base regulation and respiration. In our research, it is tried to determine the inhibitory influences of the cardiovascular therapeutics esmolol ... -
Fe3O4 Nanopowders: Genomic and Apoptotic Evaluations on A549 Lung Adenocarcinoma Cell Line
(Routledge Journals, Taylor & Francis LTD, 2019)The magnetite nanoparticles are progressively used in a wide range of biological applications. In the present study, we purposed to show apoptosis-inducing ability of Fe3O4 nanopowders on A549 cells. In addition, the toxic ... -
Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies
(Taylor & Francis LTD, 2019)Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an ... -
HepG2 hücrelerinde Vinkristin sülfat/?-viniferin kombinasyonunun vinkristin sülfat ile karşılaştırıldığında artmış etkinliğinin vurgulanması
(2016)Amaç: Bu çalışma HepG2 hücre hattında geç apoptoz ve mitokondriyal yolakta ?-viniferin (?-VNF)'in etkisini incelemek için dizayn edildi. Bu amaç için, HepG2 hücre dizisinde anti-kanser ilaç olarak kullanılan vinkristin ... -
In vitro effects of ?-tocopherol and ascorbic acid on antioxidant characteristics of HDL [?-Tokoferol ve askorbik asitin HDL'nin antioksidan özelligi üzerine in vitro etkileri]
(2011)phospholipids in low density lipoproteins (LDL) and have a capacity on inhibition of oxidative modification. These antioxidant and antiinflammatory properties are as important as its cholesterol efflux function on inhibition ... -
In vitro effects of alpha-tocopherol and ascorbic acid on antioxidant characteristics of HDL
(Turkish Biochem Soc, 2011)Aim: High density lipoprotein (HDL) retards accumulation of proinflammatuar oxidized phospholipids in low density lipoproteins (LDL) and have a capacity on inhibition of oxidative modification. These antioxidant and ... -
In vitro toxicity effects of some insecticides on gilthead sea bream (Sparus aurata) liver glucose 6-phosphate dehydrogenase
(Nobel Science and Research Center, 2016)In this study, effects of some insecticides (cypermethrin, deltamethrin, dichlorvos, imidacloprid and lambda-cyhalothrin) on glucose 6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+ oksidoreductase, EC 1.1.1.49; ... -
Induction of apoptosis in lung adenocarcinoma and glioma cells by some oxadiazole derivatives
(Springer Birkhauser, 2014)Oxadiazoles have received much attention due to their wide range of biological activities including antitumor activity. In this study, we aimed to study apoptotic effects of some 1,3,4-oxadiazole derivatives on human lung ... -
Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study
(Taylor & Francis LTD, 2017)Aldose reductase (AR) inhibitors have vital importance in the treatment and prevention of diabetic complications. In this study, rat kidney AR was purified 19.34-fold with a yield of 3.49% and a specific activity of 0.88 ... -
Inhibition effects of pesticides on glutathione-S-transferase enzyme activity of Van Lake fish liver
(Wiley, 2018)Glutathione-S-transferases (GSTs) have a function in xenobiotic metabolism. They are a significant multifunctional family with a wide variety of catalytic activities. In the current study, we determined in vitro inhibition ... -
Inhibition effects of quinones on aldose reductase: Antidiabetic properties
(Elsevier, 2019)Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a ... -
Inhibition of Human Serum Paraoxonase-I with Antimycotic Drugs: In Vitro and In Silico Studies
(Humana Press Inc., 2019)Drugs show their pharmacological effects by inhibiting or activating enzymes. Therefore, enzyme inhibitors have an essential place in the drug design for numerous different sorts of diseases, i.e., cardiovascular, cancer, ... -
Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes
(Wiley, 2017)Carbonic anhydrases (CAs, E.C.4.2.1.1) play a critical role in many important physiological events and treatment of some diseases. Flavonoids or phenolic compounds have been discovered as novel CAs inhibitors instead of ... -
Inhibitory Effects of Usnic and Carnosic Acid on Some Metabolic Enzymes: An in vitro Study
(Bentham Science Publ LTD, 2019)Background: Natural products arc produced via primary and secondary metabolism in different organisms. The compounds obtained via secondary metabolism are not essential for the survival of the organism, but they can have ... -
The interactions of cephalosporins on polyol pathway enzymes from sheep kidney
(Taylor & Francis LTD, 2018)Context: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine.Objective: An investigation of the effects on sheep renal aldose reductase ... -
Koyun Karaciğerinden Alkol Dehidrogenaz: Saflaştırma, Karakterizasyon, ve Bazı Antibiyotiklerin Etkileri
(2017)Alkol dehidrogenaz (ADH), her bir alt biriminin bir Zn2+ metal içeren katalitik alana ve bir kofaktör bağlama alanına sahip olduğu dimerik bir enzimdir. Bu enzim, alkolü, aldehide dönüştürür. Bu makale koyun karaciğerinden ... -
Mechanism of capsaicin inhibition of aldose reductase activity
(Wiley, 2017)Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive ... -
Modification of intracellular free calcium in cultured F2408 embryo fibroblasts by 3-sub substituted-2-thiohydantoin derivatives
(Wiley, 2004)3-substituted-2-thiohydantoin derivatives were synthesized and their Structures elucidated by IR, H-1-NMR spectroscopy and elemental analysis. The cytotoxicity of the 2-thiohydantoin derivatives to rat embryo fibroblasts ... -
NO levels in diabetes mellitus: Effects of l-NAME and insulin on LCAT, Na+/K+ ATPase activity and lipid profile
(Elsevier Ltd, 2011)Objectives: Diabetes mellitus (DM) is a chronic disease and one of the most important health problems. Several factors may be responsible for the complications of diabetes mellitus including alterations in the activities ...