Başlık için Makale Koleksiyonu listeleme
Toplam kayıt 86, listelenen: 13-32
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Chemical characterization and anticholinesterase effects of essential oils derived from Salvia species
(Taylor & Francis Inc, 2016)Inhibitory effect of Salvia species herbal preparations on acetylcholinesterase (AChE) and butylcholinesterase (BuChE) activitiy may contribute to regulation of cognitive performance and impaired cholinergic functions in ... -
A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells
(Turkish Pharmacists Assoc, 2019)Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt. Materials ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines
(Bentham Science Publ LTD, 2017)Background: A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. Objective: In the present work, it ... -
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
(Bentham Science Publ LTD, 2017)Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ... -
Cytotoxicity Screening, Antioxidant Activity and Phenolic Profile of Two Species of Thymus on Human Cervical and Ovarian Cancer Cells Lines in Vitro
(Parlar Scientific Publications (PSP), 2017)The aim of this study was to determine of cytotoxic, antioxidant activity and phenolic profile of the two species of Thymus which are Thymus sipyleus Boiss. and Thymus leucostomus Hausskn. et Velen. (endemic). For this ... -
Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer
(2020)Thiosemicarbazonesrepresent an important class of ligandsfortargeted therapyof many types of cancer including non-small celllung cancer. In order to identify potential antitumoragentsfor targeted therapy oflung cancer, new ... -
Determination of apoptosis on fibronectin and collagen iv adhered 5RP7 cells [Fi·bronekti·n ve kolajen iv'e bagli 5RP7 hücreleri·nde apoptozun beli·rlenmesi·]
(2009)Extracellular proteins such as fibronectin and collagen IV have a function in many cellular events such as cell growth, cell differentiation, tissue formation, cell adhesion, wound healing as well as have an important ... -
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, alpha-amylase and alpha-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia
(Elsevier Science BV, 2018)Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ... -
Direct and protective effects of single or combined addition of vincristine and epsilon-viniferin on human HepG2 cellular oxidative stress markers in vitro
(Springer, 2016)The objective of this study is to examine the direct effects of low doses and high doses of epsilon-viniferin, a substance known to be an antioxidant, and vincristine sulphate, a chemotherapeutic agent, alone and in ... -
Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base
(Wiley, 2017)Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, biotechnology, and chemical technology. Among them, amides of acids and heterocyclic compounds have an ... -
Effect of alpha lipoic acid and silymarin on bladder outlet obstruction
(Spandidos Publ LTD, 2013)The aim of the present study was to determine whether the treatment of obstructed rat bladders with alpha lipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction ... -
The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats
(Academic Journals, 2012)The objective of this study was to determine the effects of metformin treatment and exercise intervention on lipid metabolism, nitric oxide (NO), nitric oxide synthase (NOS) and glucose levels in streptozotocin-nicotinamide ... -
The effects of 1,3 bis (heteroaryl substitued) benzene derivatives on apoptosis of N-ras transformed mouse skeletal muscle cell [1,3-Bi·s (heteroari·l sübsti·tüe) benzen türevleri·ni·n N-ras transform fare kasi hücre apoptozu üzeri·ne etki·leri·]
(2005)Increasing number of the cells, results of excess divicing of the cells, is balanced by apoptosis which causes elimination of old cells and unfunctional cells. Apoptosis is a programmed cell death obtaining this balance. ... -
Effects of acetylsalicylate overdose on lipopolysaccharide-induced lung injury in rats: the role of the VEGF
(Turkish Biochem Soc, 2012)Aim: Vascular endothelial growth factor production is decreased depending on the alveolar epithelial cell damage. Acute over expression of vascular endothelial growth factor in lung tissue contributes to the formation ... -
The effects of atorvastatin on antioxidant/antiinfammatory properties of HDLs in hypercholesterolemics
(2015)Background/aim: Hypercholesterolemia is characterized by changes in lipid profle, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ... -
The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics
(Tubitak Scientific & Technical Research Council Turkey, 2015)Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ... -
The effects of captopril and losartan on erythrocyte membrane Na1+/K1+ - ATPase activity in experimental diabetes mellitus
(2007)Diabetes mellitus induces a decrease in sodium potassium-adenosine triphosphatase (Na+/K+ - ATPase) activity in several tissues in the rat and red blood cells (RBC) and nervous tissue in human patients. This decrease in ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines
(2011)Fenolik bir monoterpen olan karvakrol kekik bitkisinde bulunmaktadır ve besinlerde baharat olarak kullanılmaktadır. Bu çalışmanın amacı, karvakrol’ün H-ras transform edilmiş 5RP7 ve N-ras transform edilmiş CO25 hücreleri ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines [Karvakrol'ün H-ras ve N-ras transform hücre apoptozu üzerine etkileri]
(2011)Carvacrol is a phenolic monoterpen found in Thyme plant which is used as a source of flavour in food. The aim of this study was to investigate apoptotic effects of carvacrol on H-ras transformed 5RP7 and N-ras transformed ... -
Effects of combination of p-dimethylaminoazobenzene and dioxin on serum lipid profile
(2010)Objective: The liver cancer initiator p-dimethylaminoazobenzene and the potent liver promoter Dioxin are the environmental pollutants that people may be exposed to those in their daily lives. Butyrylcholinesterase is a ...