Başlık için Makale Koleksiyonu listeleme
Toplam kayıt 132, listelenen: 114-132
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Plasminogen Activator Inhibitor Type-1 Gene 4G/5G Polymorphism Is Associated with Hypertensive Patients in the Turkish Population
(Mary Ann Liebert Inc, 2010)This study has been performed on hypertensive patients in the Turkish population to determine the frequency of 4G/5G polymorphism genotypes of plasminogen activator inhibitor type-1 gene and with the aim of examining the ... -
The possible mechanisms of protocatechuic acid-induced central analgesia
(Elsevier Science BV, 2018)It is aimed to investigate the central antinociceptive effect of protocatechuic acid and the involvement of stimulation of opioidergic, serotonin 5-HT2A/2C. alpha 2-adrenergic and muscarinic receptors in protocatechuic ... -
Prunus spinosa L. meyvelerinin deneysel yara iyileşmesi üzerine etkileri
(2017)Farelerde oluşturduğumuz deneysel yara modellerinde, Prunus Spinosa L. metanollü meyve ekstresini kullanarak, bu ekstrenin yara iyileşmesindeki etkisini araştırdık. Otuz iki adet C57/Black fare ile 4 deney grubu oluşturuldu. ... -
Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice
(Elsevier GMBH, Urban & Fischer Verlag, 2012)In this study, the effect of Matricaria recutita L essential oil (MEO) on the central nervous system (CNS) of mice was investigated using some behavioral methods. Chemical profiling both by GC and GC-MS analyses of the ... -
Reversal of experimental digoxin toxicity in rabbits using digoxin-specific antibodies
(1987)[No abstract available] -
The Role of TRP and K+ Ion Channels in Analgesic Effect of NSAIDs
(Marmara University, Inst Health Sciences, 2018)Objective: We aimed to clarify the possible contributions of TRP and voltage-dependent K+ channels to the analgesic effects of diclofenac, ketoprofen, etodolac, and dipyrone using the nonselective TRP channel blocker ... -
Serotonerjık ve Noradrenerjık Modülasyonun Rosmarınık Asıt Analjezısıne Katkısı
(2017)Bu çalışmada, 0.3, 1 ve 3 mg/kg (p.o.) rosmarinik asitinfarelerde santral analjezik etkinliğinin sıcak-plaka vekuyruk-batırma testleri, periferal analjezik etkinliğininise asetik asit ile indüklenen kıvranma-testi ile ... -
Some new 7-aryloxyalkyltheophyllines as bronchodilators
(Editions Scientifiques Medicales Elsevier, 1997)… -
Synthesis and analgesic effects of 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives
(Springer Birkhauser, 2011)This present study was undertaken to synthesize and investigate possible analgesic activities of some 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives that were designed by combining an analgesic ... -
Synthesis and Anticancer Activity of New Hydrazide-hydrazoncs and Their Pd(II) Complexes
(Bentham Science Publ LTD, 2019)Background: Hydrazones, one of the important classes of organic molecules, are pharmaceutical agents comprising -CO-NH-N=CH- group in the structure therefore and exhibiting significant biological activity. Methods: ... -
Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives
(MDPI, 2017)Within the scope of our new antidepressant drug development efforts, in this study, we synthesized eight novel benzothiazole derivatives 3a-3h. The chemical structures of the synthesized compounds were elucidated by ... -
Synthesis and antinociceptive activities of some novel benzimidazole-piperidine derivatives
(Scientific Technical Research Council Turkey-Tubitak, 2017)In this study, a series of benzimidazole-piperidine derivatives were synthesized with the objective of developing potent antinociceptive agents. Some 2-(4-substituted-phenyl) 1 [2 (piperidin-1-yBethyl]-1 H-benzimidazole ... -
Synthesis of new 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluation of their antidepressant-like effects
(Pharmaceutical Soc Korea, 2013)In this study, we synthesized eight novel 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluated their antidepressant-like activities. The chemical structures of the synthesised compounds were elucidated ... -
Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
(MDPI, 2018)Novel benzazole derivative compounds 4a-4h were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds ... -
Synthesis of thiadiazole derivatives bearing hydrazone moieties and evaluation of their pharmacological effects on anxiety, depression, and nociception parameters in mice
(Pharmaceutical Soc Korea, 2012)Novel thiadiazole derivatives bearing hydrazone moieties were synthesized through the reaction of 2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio)]acetohydrazide with aldehydes/ketones. The chemical structures of the compounds ... -
Testing wound-healing activity in T15 fibroblast cultures: A morphometric analysis
(Frame, 2000)The purpose was to evaluate the use of mouse T15 fibroblast cell cultures for the investigation of wound-healing activity. In order to investigate their mechanisms of action, the effects of drugs with wound-healing activities ... -
Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms
(Elsevier Science BV, 2018)The purpose of this study is to assess the possible anti-allodynic and antihyperalgesic effect of valnoctamide, an amide derivative of valproic acid, at the doses of 40, 70 and 100 mg/kg (i.p.) in neuropathic pain model ... -
Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts
(Elsevier Ireland LTD, 2007)Wound-healing effect of St. John's Wort (Hypericum perforatum L.) extract was evaluated by comparing with dexpanthenol and titrated extract of Centella asiatica TECA) on cultured chicken embryonic fibroblasts. Chicken ... -
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy
(Pergamon-Elsevier Science LTD, 2014)Aims: The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role ...
