Simple method of paroxetine determination using a single channel FIA with no in-line reaction process

Abstract

A flow-injection analysis (FIA) of paroxetine hydrochloride (PRX), a selective serotonin reuptake inhibitor (SSRI) currently used as an antidepressant drug, is described. A 0.1 mol dm(-3) acetate buffer at pH 3.07 was found to be the best solvent. The analyte was detected at 293 nm. The calibration equation was linear over the range of 1.07 X 10(-6) to 5.35 x 10(-6) mol dm(-3). The limit of detection (LOD) and the limit of quantitation (LOQ) were 3.2 x 10(-7) and 9.5 x 10(-7) mol dm(-3), respectively. The proposed method was applied to the determination of PRX in pharmaceutical preparations. The results were compared with those obtained by a conventional batchwise UV-spectrophotometry.