Determination of lansoprazole in pharmaceutical capsules by flow injection analysis using UV-detection

Abstract

The direct determination of lansoprazole by using a flow injection analysis (FIA) with UV-detection and its application to the pharmaceutical capsules is described, in this study. The best carrier solvent was found to be 0.01 M NaOH and it was determined at optimum conditions such as flow rate of 1 ml min -1 and wavelength of 292 nm. Examining the repeatability of the method that was found to be 1.72% for intra-day and 2.13% for inter-day precision using the 8.01×10-6 M lansoprazole concentration has validated the method. The linear range of the method was 5.4×10 -6 to 5.4×10-5 M. The limit of detection and quantification was found to be 5.8×10-7 and 1.7×10 -6 M, respectively. The proposed method was applied to the pharmaceutical capsules and very good results obtained. Thus, the FIA method for the quantification of lansoprazole can be proposed as a cheap, rapid, easy, accurate, and precise method for the routine determination in pharmaceutical preparations