The electroanalytical behaviour of ancitabine

Abstract

The direct current polarographic behaviour of ancitabine based on the reduction of the molecule is described and the optimum polarographic conditions for its determination are presented in this study. The experiments were conducted in an aqueous supporting electrolyte containing of 0.2 M KCL and a buffer system. The effect of pH was examined in the range of 2.77 and 9.52. Well-defined and one step curves were obtained in the related pH range. The limiting currents were almost equal in the studied pH range. The polarographic current was totally diffusional and the reaction of reduction was quasi-reversible. Good results were obtained using certain polarographic techniques namely DC, SCAP, SIAP and DP. The detection limits of the techniques are found to be around 1x10-6 M and the standard error less than 2 percent. The methods proposed in this study seems to be practical of use, with a good accuracy and precision, in the determination of ancitabine.