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dc.contributor.authorTaslimi, Parham
dc.contributor.authorSujayev, Afsun
dc.contributor.authorMamedova, Sevgi
dc.contributor.authorKalin, Pınar
dc.contributor.authorGülçin, İlhami
dc.contributor.authorSadeghian, Nastaran
dc.contributor.authorMamedov, Sabir
dc.date.accessioned2019-10-19T14:02:59Z
dc.date.available2019-10-19T14:02:59Z
dc.date.issued2017
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.urihttps://dx.doi.org/10.1080/14756366.2016.1238367
dc.identifier.urihttps://hdl.handle.net/11421/12464
dc.descriptionWOS: 000392591100007en_US
dc.descriptionPubMed ID: 28100082en_US
dc.description.abstract1-(4-Methylsulfonyl)-2-thione-4-aryl-5-Z-6-methyl and oxyalkyl-imidazoles were synthesized from different tetrahydropyrimidinethiones and aryl sulfonyl chloride. These compunds were tested for metal chelating effects and to determine the phrase in which inhibition occured between two physiologically pertinent compunds and carbonic anhydrase (CA) isozymes I and II (hCA I and II), butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). AChE was detected in high concentrations in the brain and red blood cells. BChE is another enzymes that is abundant available in the liver and released into the blood in a soluble form. Newly synthesized hetaryl sulfonamides exhibited impressive inhibition profiles with Ki values in the range of 1.42-6.58 nM against hCA I, 1.72-7.41 nM against hCA II, 0.20-1.14 nM against AChE and 1.55-5.92 nM against BChE. Moreover, acetazolamide showed Ki values of 43.69 +/- 6.44 nM against hCA I and 31.67 +/- 8.39 nM against hCA II. Additionally, tacrine showed Ki values of 25.75 +/- 3.39 nM and 37.82 +/- 2.08 against AChE and BChE, respectively.en_US
dc.description.sponsorshipDistinguished Scientist Fellowship Program at King Saud Universityen_US
dc.description.sponsorshipS.H. Alwasel would like to thank the Distinguished Scientist Fellowship Program at King Saud University for financial support.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis LTDen_US
dc.relation.isversionof10.1080/14756366.2016.1238367en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAryl Sulfonyl Chloridesen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectCarbonic Anhydraseen_US
dc.subjectHeterocyclic Aminesen_US
dc.titleSynthesis and bioactivity of several new hetaryl sulfonamidesen_US
dc.typearticleen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalıen_US
dc.identifier.volume32en_US
dc.identifier.issue1en_US
dc.identifier.startpage137en_US
dc.identifier.endpage145en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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