Effects of combination of p-dimethylaminoazobenzene and dioxin on serum lipid profile

Abstract

Objective: The liver cancer initiator p-dimethylaminoazobenzene and the potent liver promoter Dioxin are the environmental pollutants that people may be exposed to those in their daily lives. Butyrylcholinesterase is a natural detoxificant that hydrolyses some xenobiotics. The relation between butyrylcholinesterase activity and lipoprotein metabolism is well documented. In this study, we aimed to determine the effects of two chemicals that had potential of liver cancer by combined administration on butyrylchonlinesterase activity and serum lipid profile. Material and Methods: p- dimethylaminoazobenzene was administered with diet as 0.06% ratio for 15 weeks and dioxin was administered weekly as 70 ng/100 g body weight for 13 weeks. At the end of the study serum LDL Cholesterol, HDL Cholesterol, Triglyceride, and Total Cholesterol levels and Butyrylcholinesterase, Lecithin: Cholesterol Acyltransferase activities were measured. Results: Butyrylcholinesterase activity was increased (p< 0.01) while LDL Cholesterol (p< 0.001), HDL Cholesterol (p< 0.01) and Total Cholesterol (p< 0.01) levels were decreased significantly in p-dimethylaminoazobenzene and dioxin treated rats. There was no change in Lecithin: Cholesterol Acyltransferase activity. Conclusion: Carcinogens with lipophilic properties increases Butyrylcholinesterase activity when administered with p-dimethylaminoazobenzene and dioxin, and interacts with lipoproteins and causes lipid protein metabolism impairments. Copyright © 2010 by Türkiye Klinikleri.