| dc.contributor.author | Orhan, İlkay Erdoğan | |
| dc.contributor.author | Atasu, Erdem | |
| dc.contributor.author | Şenol, Fatma Sezer | |
| dc.contributor.author | Öztürk, Nilgün | |
| dc.contributor.author | Demirci, Betül | |
| dc.contributor.author | Daş, Kuntal | |
| dc.contributor.author | Şekeroğlu, Nazim | |
| dc.date.accessioned | 2019-10-19T14:15:32Z | |
| dc.date.available | 2019-10-19T14:15:32Z | |
| dc.date.issued | 2013 | |
| dc.identifier.issn | 0926-6690 | |
| dc.identifier.uri | https://dx.doi.org/10.1016/j.indcrop.2013.03.022 | |
| dc.identifier.uri | https://hdl.handle.net/11421/12878 | |
| dc.description | WOS: 000319892000044 | en_US |
| dc.description.abstract | In this study, enzyme inhibitory and antioxidant activity of the ethanol extracts of Centella asiatica (L.) Urban from Turkey and India was examined and the results were compared to those of the standardized extract of the plant obtained from China. Inhibitory activity of these three extracts was screened against four enzymes; acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase (TYRO), and lipoxygenase (LOX) using ELISA microplate reader. Antioxidant activity of the extracts was determined in vitro using 2,2-diphenyl-1-picrylhydrazyl (DPPH), metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. The extracts showed a notable inhibition against BChE and TYRO, while the extracts from Turkey and India displayed lower activity in the antioxidant assays. HPLC analysis indicated that the Turkish plant sample was found to be richest in p-hydroxy-benzoic acid, whilst the Indian sample contained chlorogenic acid in the most abundant amount. alpha-Copaene was the dominant compound in the essential oil of the plant sample from Turkey | en_US |
| dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK) | en_US |
| dc.description.sponsorship | The authors would like to thank to "Phytopharma Drug and Herbal Health Products Ltd." (Ankara, Turkey) for kindly providing the standardized extract of CA imported from China. We also would like to acknowledge "Zeytinburnu Medicinal Plant Garden" (Istanbul, Turkey) for providing us with the plant material of CA. F.S. Senol would like to express her sincere thanks to the Scientific and Technological Research Council of Turkey (TUBITAK) for the scholarship provided for her Ph.D. program. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Elsevier Science BV | en_US |
| dc.relation.isversionof | 10.1016/j.indcrop.2013.03.022 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Centella Asiatica | en_US |
| dc.subject | Gotu Kola | en_US |
| dc.subject | Enzyme Inhibition | en_US |
| dc.subject | Antioxidant Activity | en_US |
| dc.subject | Phenolic Acid | en_US |
| dc.subject | Essential Oil | en_US |
| dc.title | Comparative studies on Turkish and Indian Centella asiatica (L.) Urban (gotu kola) samples for their enzyme inhibitory and antioxidant effects and phytochemical characterization | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Industrial Crops and Products | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı | en_US |
| dc.identifier.volume | 47 | en_US |
| dc.identifier.startpage | 316 | en_US |
| dc.identifier.endpage | 322 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.institutionauthor | Öztürk, Nilgün | |
| dc.contributor.institutionauthor | Demirci, Betül | |
