| dc.contributor.author | Göğer, Fatih | |
| dc.contributor.author | Özek, Gülmira | |
| dc.contributor.author | Tekin, M. | |
| dc.contributor.author | Yur, S. | |
| dc.contributor.author | Özek, Temel | |
| dc.date.accessioned | 2019-10-19T14:16:16Z | |
| dc.date.available | 2019-10-19T14:16:16Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 2149-0120 | |
| dc.identifier.uri | https://dx.doi.org/10.18596/jotcsa.516888 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13115 | |
| dc.description.abstract | In the present study, the extract of an endemic plant ourkey Marrubium sivasense Aytaç, Akgül & Ekici was investigated for phytochemical profile, antioxidant properties and inhibition of several enzymes. The chemical composition of the extract was investigated with LC-MS/MS technique. Forsythoside B, verbascoside and leucoseptoside were identified as the main compounds. The free radical scavenging activity of the extract was determined against DPPH• radicals (IC50 0.34 mg/mL) and ABTS•+ cation radicals (TEAC 2.3 mM). In the xanthine-xanthine oxidase (XO) system and in ß-carotene bleaching assay the extract demonstrated moderate activity (Inh% 16.54 and Inh% 43±1.26, respectively). The extract demonstrated hypoglycemic activity (Inh% 49.67±1.09) via inhibition of porcine pancreatic ?-amylase. The antiinflammatory effect tested via inhibition of 5-LOX was found as Inh% 18.71±0.74. However, no antityrosinase activity was found | en_US |
| dc.description.sponsorship | 1705S171 | en_US |
| dc.description.sponsorship | Authors are grateful to Anadolu University Scientific Research Department for supporting this research project (Grant Number 1705S171). | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Turkish Chemical Society | en_US |
| dc.relation.isversionof | 10.18596/jotcsa.516888 | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Antioxidant | en_US |
| dc.subject | Extract | en_US |
| dc.subject | Lc-Ms/Ms | en_US |
| dc.subject | Marrubium Sivasense | en_US |
| dc.subject | Tyrosinase | en_US |
| dc.subject | Xanthine Oxidase | en_US |
| dc.subject | ?-Amylase | en_US |
| dc.title | Phytochemical profiling and evaluation of marrubium sivasense aytaç, akgül & ekici for antioxidant activity and inhibition effects on ?-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Journal of the Turkish Chemical Society, Section A: Chemistry | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı | en_US |
| dc.identifier.volume | 6 | en_US |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.startpage | 281 | en_US |
| dc.identifier.endpage | 292 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.institutionauthor | Göğer, Fatih | |
| dc.contributor.institutionauthor | Özek, Gülmira | |
| dc.contributor.institutionauthor | Özek, Temel | |
