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dc.contributor.authorArslan, Rana
dc.contributor.authorBektaş, Nurcan
dc.contributor.authorBor, Zeynep
dc.contributor.authorŞener, Erol
dc.date.accessioned2019-10-19T14:16:22Z
dc.date.available2019-10-19T14:16:22Z
dc.date.issued2015
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.urihttps://dx.doi.org/10.3109/13880209.2014.914957
dc.identifier.urihttps://hdl.handle.net/11421/13141
dc.descriptionWOS: 000348493200015en_US
dc.descriptionPubMed ID: 25243870en_US
dc.description.abstractContext: Crataegus species are widely used as herbal medicines for preventing cardiovascular diseases (CVDs). However, there are no studies on the effects of Crataegus monogyna Jacq. (Rosaceae) and C. davisii Browicz on thrombosis, which is an important mechanism in CVDs. Objective: The purpose of this study was to investigate the antithrombotic effects of ethanol extracts of Crataegus monogyna (CMEx) and C. davisii (CDEx) leaves by using the carrageenaninduced tail thrombosis model. Materials and methods: The hind paw of each mouse was injected with 1% Type I carrageenan to induce thrombosis. CMEx was tested at the doses of 100, 200, and 300 mg/kg and CDEx at the dose of 50, 100, 200, and 300 mg/kg in comparison with heparin. The lengths of tail thrombosis were measured at the 24, 48, and 72 h. Results: Does of 200 and 300 mg/kg CMEx showed significant effects (p<0.01; p<0.001) at 24 h when compared with the control group. The antithrombotic activity of 200 and 300 mg/kg CMEx showed a decrease at 48 and 72 h but the activity of 300 mg/kg dose of CMEx was still significant (p<0.01). The activities of 50 and 100 mg/kg doses of CDEx were significant (p<0.001; p<0.01) between 24 and 72 h whereas 200 and 300 mg/kg CDEx did not show any significance. Discussion and conclusions: CMEx and CDEx significantly inhibited the carrageenan-induced mouse tail thrombosis. Based on these results, it was concluded that CDEx and CMEx may potentially be used as therapeutic agents or complementary treatments against thrombosis.en_US
dc.description.sponsorshipScientific Research Projects Foundation of Anadolu University, Eskisehir, Turkey [090331]en_US
dc.description.sponsorshipThe authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. Financial support for this work through the Scientific Research Projects Foundation of Anadolu University, Eskisehir, Turkey is gratefully acknowledged (Project code no: 090331).en_US
dc.language.isoengen_US
dc.publisherInforma Healthcareen_US
dc.relation.isversionof10.3109/13880209.2014.914957en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntithrombotic Effectsen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectHemostasisen_US
dc.subjectHawthornen_US
dc.titleEvaluation of the antithrombotic effects of Crataegus monogyna and Crataegus davisii in the carrageenan-induced tail thrombosis modelen_US
dc.typearticleen_US
dc.relation.journalPharmaceutical Biologyen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalıen_US
dc.identifier.volume53en_US
dc.identifier.issue2en_US
dc.identifier.startpage275en_US
dc.identifier.endpage279en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorArslan, Rana
dc.contributor.institutionauthorBektaş, Nurcan


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