Kurum Yazarı "Altıntop, Mehlika Dilek" Makale Koleksiyonu İçin Listeleme
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A novel series of thiazolyl-pyrazoline derivatives: Synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirel, Rasime; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the current work, new thiazolyl pyrazoline derivatives (1-22) were synthesized and evaluated for their antifungal effects against pathogenic yeasts and molds using a broth microdilution assay. Ames assay was carried out ... -
Potential inhibitors of human carbonic anhydrase isozymes I and II: Design, synthesis and docking studies of new 1,3,4-thiadiazole derivatives
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Küçükoğlu, Kaan; Onem, Hicran; Nadaroğlu, Hayrunnisa; Kaplancıklı, Zafer Asım (Pergamon-Elsevier Science LTD, 2017)In the last years, inhibition of carbonic anhydrase (CA) has emerged as a promising approach for pharmacologic intervention in a variety of disorders such as glaucoma, epilepsy, obesity, and cancer. As a consequence, the ... -
A Survey about Pharmacy Technicians in Eskisehir
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin (Çukurova University, Fac Medicine, 2015)Purpose: In the current work, we aimed to carry out a research on the evaluation of pharmacy technicians from the perspective of pharmacists in Eskisehir. Material and Methods: The pharmacists of this test were chosen by ... -
Synthesis and analgesic activity of some acetamide derivatives
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Turan, Gülhan; Özdemir, Ahmet; Can, Özgür Devrim (Informa Healthcare, 2012)In the present study, some acetamide derivatives were synthesized and their potential analgesic activities were investigated. N-(benzothiazol-2-yl)-2-[(1-substituted-1H-tetrazol-5-yl) thio] acetamide derivatives were ... -
Synthesis and anticandidal activity of new triazolothiadiazine derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; İşcan, Gökalp; Akalın Çiftçi, Gülsen; Yıldırım, Şafak Ulusoylar (Elsevier France-Editions Scientifiques Medicales Elsevier, 2011)New triazolothiadiazine derivatives were synthesized via the ring closure reaction of 4-amino-5-substituted-2,4-dihydro-3H-1,2,4-triazol-3-thiones with phenacyl bromides. The compounds were tested in vitro against various ... -
Synthesis and Anticholinesterase Activity and Cytotoxicity of Novel Amide Derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Temel, Halide Edip; Akalın Çiftçi, Gülsen (Wiley-V C H Verlag GMBH, 2012)In the present study, some amide derivatives were synthesized and their potential anticholinesterase properties were investigated. N-(Benzothiazol-2-yl)-2-[(5-amino/methyl-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives ... -
Synthesis and antifungal activity of new hydrazide derivatives
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Demirci, Fatih; Abu Mohsen, Usama; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2013)In this study, nine new hydrazide derivatives were synthesized. The reaction of 2-[(5,6,7,8-tetrahydronaphthalen-2-yl) oxy]acetohydrazide with various benzaldehydes or acetophenones resulted in N'-substituted-2-[(5,6,7,8 ... -
Synthesis and antimicrobial activity of benzimidazole-based acetamide derivatives
Altıntop, Mehlika Dilek; Abu Mohsen, Usama; Özkay, Yusuf; Demirel, Rasime; Kaplancıklı, Zafer Asım (Turkish Pharmacists Association, 2015)In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity. Among these derivatives, compounds 2b-2g were found to be the most promising ... -
Synthesis and Biological Evaluation of a New Series of Pyrazolines as New Anticandidal Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Çiftçi, Gülsen Akalın; Demirci, Fatih (Springer, 2014)New pyrazoline derivatives bearing an oxadiazole moiety were synthesized via the reaction of 1-(chloroacetyl)-3-(2-furyl/thienyl)-5-aryl-2-pyrazolines with 5-substituted-1,3,4-oxadiazole-2(3H)-thiones in the presence of ... -
Synthesis and Biological Evaluation of a Series of Dithiocarbamates as New Cholinesterase Inhibitors
Altıntop, Mehlika Dilek; Gürkan-Alp, A. Selen; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Wiley-V C H Verlag GMBH, 2013)In the present paper, a novel series of dithiocarbamates was synthesized via the treatment of 4-(trifluoromethyl)benzyl chloride with appropriate sodium salts of N,N-disubstituted dithiocarbamic acids. H-1 NMR, mass spectral ... -
Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents
Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Ilgın, Sinem; Demirel, Rasime; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New thiosemicarbazone derivatives (1-10) were obtained via the reaction of 4-(naphthalen-1-yl)thiosemicarbazide with fluoro-substituted aromatic aldehydes. The synthesized compounds were evaluated for their in vitro ... -
Synthesis and Biological Evaluation of New Pyrazole-based Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Ilgın, Sinem; Atlı Eklioğlu, Özlem (Bentham Science Publ LTD, 2014)New pyrazole-based thiazolyl hydrazone derivatives were obtained via the ring closure reaction of 3,5-dimethyl-1H-1-phenylpyrazole-4-carboxaldehyde thiosemicarbazone with 2-bromoacetophenone derivatives. The compounds were ... -
Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents
Erguc, Ali; Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Sever, Belgin; İşcan, Gökalp; Gormus, Gözde; Özdemir, Ahmet (Bentham Science Publ LTD, 2018)Background: In medicinal chemistry, thiazoles have gained great importance in anti-fungal and anticancer drug design and development. Objectives: The aim of this study was to synthesize new quinoline-based thiazolyl hydrazone ... -
Synthesis and Biological Evaluation of Pyrazoline Derivatives Bearing an Indole Moiety as New Antimicrobial Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Karaca Gencer, Hülya; Tunalı, Yağmur (Wiley-V C H Verlag GMBH, 2013)1-(p-Methylphenyl)-3,5-diaryl-2-pyrazoline derivatives (2a-f) were synthesized via the treatment of 1-(1H-indol-3-yl)-3-aryl-2-propen-1-ones (1a-f) with p-methylphenylhydrazine hydrochloride in hot acetic acid. The structures ... -
Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Turan, Gülhan; İşcan, Gökalp; Çiftçi, Gülsen Akalın (Bentham Science Publ LTD, 2013)In this study, N-(benzothiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives (1-24) were obtained by the reaction of 2-chloro-N-(benzothiazole-2-yl)acetamides with piperidine derivatives. The structures of the compounds ... -
Synthesis and Biological Evaluation of Some Hydrazone Derivatives as Anti-inflammatory Agents
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Khan, Shabana I.; Tabanca, Nurhayat (Bentham Science Publ LTD, 2012)In the present study, some hydrazone derivatives were synthesized via the reaction of 3-cyclohexylpropionic acid hydrazide with various benzaldehydes. The chemical structures of the compounds were elucidated by spectroscopic ... -
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; İşcan, Gökalp; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)New hydrazone derivatives were synthesized via the nucleophilic addition-elimination reaction of 2-[(1-methyl-1H-tetrazol-5-yl]thio)]acetohydrazide with aromatic aldehydes/ketones. The compounds were tested in vitro against ... -
Synthesis and Biological Evaluation of Some Pyrazoline Derivatives Bearing a Dithiocarbamate Moiety as New Cholinesterase Inhibitors
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Turan, Gülhan; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Wiley-V C H Verlag GMBH, 2013)In the present study, new pyrazoline derivatives were synthesized via the reaction of 1-(chloroacetyl)-3-(2-furyl)-5-aryl-2-pyrazolines with sodium salts of N,N-disubstituted dithiocarbamic acids. Each derivative was ... -
Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors
Turan, Gülhan; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Informa Healthcare, 2013)In the present study, some thiazole derivatives were synthesized via the ring closure reaction of 1-[2-(2-oxobenzo[d] thiazol-3(2H)-yl)acetyl]thiosemicarbazide with various phenacyl bromides. The chemical structures of the ... -
Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents
Özdemir, Ahmet; gökbulut, Sevtem; Sever, Belgin; Çiftçi, Gülsen Akalın; Altıntop, Mehlika Dilek (Bentham Science Publ LTD, 2018)Background: Arylidene indanones have attracted a great deal of interest due to their outstanding therapeutic applications. In particular, considerable research has pointed out the importance of arylidene indanones in the ...