Yazar "Çevik, Ulviye Acar" için Makale Koleksiyonu listeleme
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Anticholinesterase activity screening of some novel dithiocarbamate derivatives including piperidine and piperazine moieties
Levent, Serkan; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Can, Özgür Devrim; Özkay, Ümide Demir; Uçucu, Ümit (Taylor & Francis LTD, 2017)The present study was undertaken to synthesize some novel lipophilic piperazine and piperidinedithiocarbamates and investigate their inhibitory potencies against cholinesterase enzymes. In the synthetic studies, 44 new ... -
Antiproliferative, Cytotoxic, and Apoptotic Effects of New Benzimidazole Derivatives Bearing Hydrazone Moiety
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Korkut, Büşra; Özkay, Yusuf; Ilgın, Sinem (Wiley, 2018)In order to take the advantages of the anticancer properties of benzimidazoles and hydrazones, we synthesized new 4-(5-chloro-1H-benzimidazol-2-yl)-benzoic acid benzylidene hydrazide derivatives (3a-3t) and evaluated their ... -
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
Sağlık, Begüm Nurpelin; Kaya Çavuşoğlu, Betül; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Ilgın, Sinem; Öztürk, Yusuf (Academic Press Inc Elsevier Science, 2019)New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to determine the biological effects of synthesized ... -
Novel imidazole derivatives as antifungal agents: Synthesis, biological evaluation, ADME prediction and molecular docking studies
Altındağ, Firuze Diyar; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Işıkdağ, İlhan; Özkay, Yusuf; Karaca Gencer, Hülya (Taylor & Francis LTD, 2019)A series of 2-(substituteddithiocarbamoyl)-N-[4-((1H-imidazol-1-yl)methyl)phenyl]acetamide derivatives was designed and synthesized to combat the increasing incidence of drug-resistant fungal infections. All synthesized ... -
Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Levent, Serkan; Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2019)Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly ... -
Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
Kaplancıklı, Zafer Asım; Levent, Serkan; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Ilgın, Sinem (MDPI, 2017)Azole-based antifungal agents constitute one of the important classes of antifungal drugs. Hence, in the present work, 12 new benzimidazole-thiazole derivatives 3a-3l were synthesized to evaluate their anticandidal activity ... -
Synthesis and Anticandidal Activity of New Imidazole-Chalcones
Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI, 2018)In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl) prop-2-en-1-one derivatives (3a-3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole ... -
Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
Karaburun, Ahmet Çağrı; Kaya Çavuşoğlu, Betül; Çevik, Ulviye Acar; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Levent, Serkan; Kaplancıklı, Zafer Asım (MDPI, 2019)Discovery of novel anticandidal agents with clarified mechanisms of action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to existing drugs. In support to this ... -
Synthesis and antimicrobial activities of some novel thiazole compounds
Turan, Gülhan; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar (Walter De Gruyter GMBH, 2018)Objective: The advent of resistant pathogenic microorganisms against current antimicrobial drugs prompted scientists to investigate novel molecules with new mechanisms. In this paper, some new 2-[2-[4-(ethyl/phenyl)cyclo ... -
Synthesis and antimicrobial activity of new 2-((1-furan-2-yl)ethylidene)hydrazono)-4-phenylthiazol-3(2H)-amine derivatives and their schiff bases with 4-nitrobenzaldehyde
Turan, Gülhan; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Levent, Serkan; Ilgın, Sinem; Hussein, Weiam (Taylor & Francis LTD, 2018)A new series of 2-((1-furan-2-yl)ethylidene)hydrazono)-4-substitutedphenylthiazol-3(2H)-amines (2a-2o) and their Schiff bases (3a-3o) from 4-nitrobenzaldehyde were synthesized. The chemical structures of all the synthesized ... -
Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Karaduman, Abdullah Burak; Kaplancıklı, Zafer Asım (MDPI, 2018)Twenty-six novel thiosemicarbazone derivative B1-B26 were synthesized via condensation reactions between the corresponding thiosemicarbazides and aldehydes. The chemical characterization of the compounds was carried out ... -
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
Karaburun, Ahmet Çağrı; Çevik, Ulviye Acar; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Kaya Çavuşoğlu, Betül; Levent, Serkan; Kaplancıklı, Zafer Asım (MDPI, 2018)With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a-3l) were synthesized and characterized. Due to thione-thiol tautomerism in the ... -
Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Ardıç, Cankiz Mina; Özkay, Yusuf; Atlı Eklioğlu, Özlem (Walter De Gruyter GMBH, 2018)Objectives: Cancer is one of the leading causes of death throughout the world. Current therapy options suffer from the major limitations of side effects and drug resistance. Thus, continuing search for newer and safer ... -
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Cantürk, Zerrin; Bueno, Juan; Demirci, Fatih; Koparal, Ali Savaş (Bentham Science Publ LTD, 2017)In the present study, nineteen new fluoro-benzimidazole derivatives, including nifuroxazide analogs, were synthesized by microwave-supported reactions and tested against a panel of pathogenic microorganisms consisting of ... -
Synthesis of Novel 4-(Dimethylaminoalkyl) piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors
Çevik, Ulviye Acar; Levent, Serkan; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Carbamate compounds have attracted a great deal of interest in medicinal chemistry due to their inhibition potential against cholinesterase enzymes. Method: Hence, this study was undertaken to synthesize new ... -
Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
Levent, Serkan; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI AG, 2017)In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel ... -
Synthesis, Characterization, and Molecular Docking Study of Some Novel Imidazole Derivatives as Potential Antifungal Agents
Işık, Ayşen; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf (Wiley, 2019)The azole pharmacophore is still regarded as a viable lead structure for the synthesis of more effective antifungal agents. In this study, two novel series of imidazole derivatives containing dithiocarbamate (5a-5g) and ... -
Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives
Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Kaya Çavuşoğlu, Betül; Demir, Y. (NLM (Medline), 2019)New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II ...