Yazar "Demirci, Fatih" için Makale Koleksiyonu listeleme
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Carbazoles and Hydrazone-Bridged Thiazole-Pyrrole Derivatives as New Inhibitors of alpha-Glucosidase
Ghani, Usman; Albarrag, Ahmed; Yurttaş, Leyla; Demirci, Fatih; Kaplancıklı, Zafer Asım (Wiley-V C H Verlag GMBH, 2018)Carbazoles and hydrazone-bridged thiazole-pyrrole derivatives are known to exhibit a wide range of biological activities including antimicrobial activity. This work is a further extension of their biological activities ... -
Preparation of some pyrazoline derivatives and evaluation of their antifungal activities
Özdemir, Ahmet; Turan, Gülhan; Kaplancıklı, Zafer Asım; Revıal, Gilbert; Demirci, Fatih; İşcan, Gökalp (Informa Healthcare, 2010)The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. ... -
Studies on hydrazone derivatives as antifungal agents
Özdemir, Ahmet; Turan, Gülhan; Kaplancıklı, Zafer Asım; Demirci, Fatih; İşcan, Gökalp (Taylor & Francis LTD, 2008)The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(ar ... -
Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Göğer, Gamze; Demirci, Fatih (Taylor & Francis LTD, 2016)In this study, we have performed the synthesis of new N-(arylidene)-4-[(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a-s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target ... -
Synthesis and antifungal activity of new hydrazide derivatives
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Demirci, Fatih; Abu Mohsen, Usama; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2013)In this study, nine new hydrazide derivatives were synthesized. The reaction of 2-[(5,6,7,8-tetrahydronaphthalen-2-yl) oxy]acetohydrazide with various benzaldehydes or acetophenones resulted in N'-substituted-2-[(5,6,7,8 ... -
Synthesis and antimicrobial activity evaluation of new hydrazide derivatives [Yeni Hidrazid Türevlerinin Sentezi ve Bunlari{dotless}n Antimikrobiyal Aktivitelerinin Degerlendirilmesi]
The enhancement of bacterial resistance of pathogens to currently available antibiotics constitutes a serious public health threat. Therefore, intensive efforts are underway worldwide to develop new antimicrobial agents. ... -
Synthesis and Antimicrobial Activity of New Pyrimidine-Hydrazones
Kaplancıklı, Zafer Asım; Yurttaş, Leyla; Turan, Gülhan; Özdemir, Ahmet; Göğer, Gamze; Demirci, Fatih; Abu Mohsen, Usama (Bentham Science Publ LTD, 2014)The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide ... -
Synthesis and Biological Evaluation of a New Series of Pyrazolines as New Anticandidal Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Çiftçi, Gülsen Akalın; Demirci, Fatih (Springer, 2014)New pyrazoline derivatives bearing an oxadiazole moiety were synthesized via the reaction of 1-(chloroacetyl)-3-(2-furyl/thienyl)-5-aryl-2-pyrazolines with 5-substituted-1,3,4-oxadiazole-2(3H)-thiones in the presence of ... -
Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Temel, Halide Edip; Atlı Eklioğlu, Özlem; Baysal, Merve; Demirci, Fatih (MDPI, 2017)Matrix metalloproteinases (MMPs) are important proteases involved in tumor progression including angiogenesis, tissue invasion, and migration. Therefore, MMPs have been reported as potential diagnostic and prognostic ... -
Synthesis and Evaluation of Thiazole - Pyrimidine Derivatives as New Anticandidal and Cytotoxic Agents
Turan, Gülhan; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Demirci, Fatih; Ilgın, Sinem; Göğer, Gamze (Springer, 2014)The aim of this study was to describe the synthesis of four new 2-(3,4-diphenyl-3H-thiazol-2-ylidene)amino-4,6-dimethylpyrimidine derivatives, which were screened for their anticandidal activity and cytotoxicity. The title ... -
Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirci, Fatih; Kaplancıklı, Zafer Asım (MDPI AG, 2014)Fourteen new thiazolyl hydrazone derivatives were synthesized and evaluated for their anticandidal activity using a broth microdilution assay. Among the synthesized compounds, 2-[2-((5-(4-chloro-2-nitrophenyl) furan-2-yl) ... -
Synthesis and In Vitro Evaluation of Some Hydrazone Derivatives as Potential Antibacterial Agents
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Göğer, Gamze; Demirci, Fatih (Bentham Science Publ LTD, 2014)Nineteen N'-(benzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazides were obtained via the nucleophilic addition-elimination reaction of 2-[(pyrimidin-2-yl)thio)]acetohydrazide with aromatic aldehydes. The synthesized compounds ... -
Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives
Özdemir, Ahmet; Turan, Gülhan; Kaplancıklı, Zafer Asım; İşcan, Gökalp; Khan, Shabana I.; Demirci, Fatih (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Even though there are new classes of compounds now frequently used in treatment of fungal infections, the density of deeply invasive candidiasis has increased at least 10-fold during the past decade. Furthermore, many ... -
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Cantürk, Zerrin; Bueno, Juan; Demirci, Fatih; Koparal, Ali Savaş (Bentham Science Publ LTD, 2017)In the present study, nineteen new fluoro-benzimidazole derivatives, including nifuroxazide analogs, were synthesized by microwave-supported reactions and tested against a panel of pathogenic microorganisms consisting of ... -
Synthesis of Some Novel Triazole Derivatives and Investigation of Their Antimicrobial Activities
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; Demirci, Fatih; İşcan, Gökalp; Revial, Gilbert (Taylor & Francis Inc, 2011)[image omitted] The aim of this study is to synthesize new triazole derivatives and investigate their antimicrobial activities. 4-Amino-5-(2-cyclohexylethyl)-3-[N-(benzothiazole-2-yl)acetamido]thio-4H-1,2,4-triazole and ... -
Synthesis, Antibacterial and Antifungal Activities of Some Carbazole Dithiocarbamate Derivatives
Karaburun, Ahmet Çağrı; Kaplancıklı, Zafer Asım; Gündoğdu-Karaburun, Nalan; Demirci, Fatih (Bentham Science Publ LTD, 2011)In this study, we aimed at the synthesis of new N, N-disubstituted dithiocarbamoic acid, 2-[(9-ethyl-9H-carbazol-3-yl) amino]-2-oxoethyl esters and their antimicrobial evaluations. The chemical structures of the compounds ... -
Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains
Yurttaş, Leyla; Özkay, Yusuf; Demirci, Fatih; Göğer, Gamze; Yıldırım, Şafak Ulusoylar; Abu Mohsen, Usama; Kaplancıklı, Zafer Asım (Scientific Technical Research Council Turkey-Tubitak, 2014)Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a-j) were confirmed by ...