Yazar "Osmaniye, Derya" için Makale Koleksiyonu listeleme
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Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Osmaniye, Derya; Sağlık, Begüm Nurpelin, Begüm N.; Özdemir, Ahmet (Wiley-V C H Verlag GMBH, 2018)In an effort to develop potent monoamine oxidase (MAO) inhibitors, new pyrrole derivatives were obtained via the selective reduction of the CC bonds of 1-(1-methyl-1H-pyrrol-2-yl)-3-[5-(aryl)furan-2-yl]prop-2-en-1-ones ... -
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
Sağlık, Begüm Nurpelin; Kaya Çavuşoğlu, Betül; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Ilgın, Sinem; Öztürk, Yusuf (Academic Press Inc Elsevier Science, 2019)New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to determine the biological effects of synthesized ... -
Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
Osmaniye, Derya; Sağlık, Begüm Nurpelin; Acar Çevik, Ulviye; Levent, Serkan; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Turan, Gülhan (MDPI, 2019)Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life ... -
Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Levent, Serkan; Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2019)Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly ... -
Synthesis and anticancer activity of some novel benzothiazole-thiazolidine derivatives
Osmaniye, Derya; Levent, Serkan; Ardıç, Cankiz Mina; Atlı Eklioğlu, Özlem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2018)Sixteen new 2-(benzothiazol-2-ylthio)-N-(3-substituted-4-(3,4-substitutedphenyl)thiazol-2(3H)-ylidene)acetohydrazide derivatives (4a-4p) were synthesized. The structures of the synthesized compounds were elucidated using ... -
Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
Kaplancıklı, Zafer Asım; Levent, Serkan; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Ilgın, Sinem (MDPI, 2017)Azole-based antifungal agents constitute one of the important classes of antifungal drugs. Hence, in the present work, 12 new benzimidazole-thiazole derivatives 3a-3l were synthesized to evaluate their anticandidal activity ... -
Synthesis and Anticandidal Activity of New Imidazole-Chalcones
Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI, 2018)In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl) prop-2-en-1-one derivatives (3a-3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole ... -
Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
Karaburun, Ahmet Çağrı; Kaya Çavuşoğlu, Betül; Çevik, Ulviye Acar; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Levent, Serkan; Kaplancıklı, Zafer Asım (MDPI, 2019)Discovery of novel anticandidal agents with clarified mechanisms of action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to existing drugs. In support to this ... -
Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Karaduman, Abdullah Burak; Kaplancıklı, Zafer Asım (MDPI, 2018)Twenty-six novel thiosemicarbazone derivative B1-B26 were synthesized via condensation reactions between the corresponding thiosemicarbazides and aldehydes. The chemical characterization of the compounds was carried out ... -
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
Karaburun, Ahmet Çağrı; Çevik, Ulviye Acar; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Kaya Çavuşoğlu, Betül; Levent, Serkan; Kaplancıklı, Zafer Asım (MDPI, 2018)With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a-3l) were synthesized and characterized. Due to thione-thiol tautomerism in the ... -
Synthesis and evaluation of new pyrazoline-thiazole derivatives as monoamine oxidase inhibitors
Acar, Çevik, U.; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Levent, Serkan; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Kaplancıklı, Zafer Asım (HeteroCorporation, 2019)A novel series of 1,3,5-trisubstituted-2-pyrazoline derivatives (4a-4k) was synthesized and their chemical structures characterized by 1H NMR, 13C NMR, and mass spectroscopy. These compounds were evaluated as inhibitors ... -
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
Osmaniye, Derya; Levent, Serkan; Karaduman, Abdullah Burak; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at ... -
Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
Levent, Serkan; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI AG, 2017)In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel ... -
Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities
Can, Nafiz Öncü; Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir (MDPI, 2018)Novel thiadiazole derivatives were synthesized through the reaction of acetylated 2-aminothiadiazole and piperazine derivatives. The chemical structures of the compounds were clarified by Infrared Spectroscopy (IR), H-1 ... -
Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives
Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Kaya Çavuşoğlu, Betül; Demir, Y. (NLM (Medline), 2019)New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II ...