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Synthesis and Evaluation of Heterocycles Based Chalcone Derivatives as Anti-proliferative Agents
(Bentham Science Publ LTD, 2018)
Background: The lack of selectivity and development of drug-resistance encourage researchers to search for novel, more efficient and multi-targeted agents with less toxicity. Objective: In this paper, a series of novel ...
Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
(MDPI, 2019)
Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly ...
Design, synthesis, monoamine oxidase inhibition and docking studies of new dithiocarbamate derivatives bearing benzylamine moiety
(Academic Press Inc Elsevier Science, 2018)
A new series of thirteen 2-[(4-fluorophenyl)(4-nitrobenzyl) amino]-2-oxoethyl-1-substituted-carbodithio ate derivatives (4a-4m) were synthesized and tested for their human monoamine oxidase A and B (hMAO-A and hMAO-B) ...
Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
(MDPI, 2019)
Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life ...
Synthesis and evaluation of new pyrazoline-thiazole derivatives as monoamine oxidase inhibitors
(HeteroCorporation, 2019)
A novel series of 1,3,5-trisubstituted-2-pyrazoline derivatives (4a-4k) was synthesized and their chemical structures characterized by 1H NMR, 13C NMR, and mass spectroscopy. These compounds were evaluated as inhibitors ...