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dc.contributor.authorAydın, Yasemin
dc.contributor.authorKutlay, Özden
dc.contributor.authorArı, Senem
dc.contributor.authorDuman, Seval
dc.contributor.authorUzuner, Kubilay
dc.contributor.authorAydın, Süleyman
dc.date.accessioned2019-10-19T14:43:54Z
dc.date.available2019-10-19T14:43:54Z
dc.date.issued2007
dc.identifier.issn0032-0943
dc.identifier.urihttps://dx.doi.org/10.1055/s-2007-990236
dc.identifier.urihttps://hdl.handle.net/11421/13280
dc.descriptionWOS: 000250868600003en_US
dc.descriptionPubMed ID: 17924312en_US
dc.description.abstractCarvacrol is the major compound of essential oils of many plants, ethnomedically used for centuries but there were no detailed investigations on its action on the cardiovascular system. The aim of our study was to investigate the role of carvacrol on the cardiovascular functions of anesthetized rats and in vitro of isolated rat aorta. Carvacrol (100 mu g/kg, i.p.) decreased heart rate, mean arterial pressure and systolic and diastolic blood pressures of the anesthetized rats whereas there were no effects at 1, 10 and 20 mu g/kg. Carvacrol was observed to exhibit hypotension and to inhibit N(omega)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension. The lack of inhibitory action of carvacrol (10(-4) M) on the CaCl2- and phenylephrine-induced contractions of isolated rat aorta showed that neither adrenergic receptors nor voltage-dependent vascular L-type calcium channels were involved. But, based on previous investigations, the involvement of cardiac L-type calcium channel blocking actions are suggested for the hypotensive actions of carvacrol was assumed.en_US
dc.language.isoengen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.isversionof10.1055/s-2007-990236en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMonoterpenesen_US
dc.subjectCarvacrolen_US
dc.subjectBlood Pressureen_US
dc.subjectInhibitionen_US
dc.titleHypotensive effects of carvacrol on the blood pressure of normotensive ratsen_US
dc.typearticleen_US
dc.relation.journalPlanta Medicaen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalıen_US
dc.identifier.volume73en_US
dc.identifier.issue13en_US
dc.identifier.startpage1365en_US
dc.identifier.endpage1371en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorAydın, Süleyman


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