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dc.contributor.authorKaplancıklı, Zafer Asım
dc.contributor.authorTuran, Gülhan
dc.contributor.authorÖzdemir, Ahmet
dc.contributor.authorRevıal, Gilbert
dc.date.accessioned2019-10-19T14:44:30Z
dc.date.available2019-10-19T14:44:30Z
dc.date.issued2008
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejmech.2007.03.019
dc.identifier.urihttps://hdl.handle.net/11421/13537
dc.descriptionWOS: 000253274300018en_US
dc.descriptionPubMed ID: 17499887en_US
dc.description.abstractTriazole and triazoles fused with six-membered ring systems are found to possess diverse applications in the fields of medicine, agriculture and industry. The new 1,2,4-triazole and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine derivatives were synthesized as novel antimicrobial agents. The reaction of 1H-indol-3-acetic acid with thiocarbohydrazide gave the 4-amino-3-mercapto-5-[(1H-indol-3-yl)methyl]-4H-1,2,4-triazole. The reaction of triazole with arylaldehydes in ethanol gave the 4-arylideneamino-3-mercapto-5-[(1H-indol-3-yl)methyl]-4H-1,2,4-triazoies (1). The 3[(1H-indol-3-yl)methyl]-6-aryl-7H-1,2,4-triazolo[3,4-b]]1,3,4]thiadiazines II) were obtained by condensing triazole with phenacyl bromides in absolute ethanol. The chemical structures of the compounds were elucidated by IR, H-1 NMR and FAB(+)-MS spectral data. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans and Candida glabrata (isolates obtained from Osmangazi University, Faculty of Medicine) were investigated and significant activity was obtaineden_US
dc.language.isoengen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.isversionof10.1016/j.ejmech.2007.03.019en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIndoleen_US
dc.subjectTriazoleen_US
dc.subjectTriazolothiadiazineen_US
dc.subjectAntimicrobial Activityen_US
dc.titleNew triazole and triazolothiadiazine derivatives as possible antimicrobial agentsen_US
dc.typearticleen_US
dc.relation.journalEuropean Journal of Medicinal Chemistryen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalıen_US
dc.identifier.volume43en_US
dc.identifier.issue1en_US
dc.identifier.startpage155en_US
dc.identifier.endpage159en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorKaplancıklı, Zafer Asım
dc.contributor.institutionauthorTuran, Gülhan
dc.contributor.institutionauthorÖzdemir, Ahmet


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