dc.contributor.author | Özkay, Yusuf | |
dc.contributor.author | Tunalı, Yağmur | |
dc.contributor.author | Karaca, Hülya | |
dc.contributor.author | Işıkdağ, İlhan | |
dc.date.accessioned | 2019-10-19T14:44:43Z | |
dc.date.available | 2019-10-19T14:44:43Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0365-6233 | |
dc.identifier.uri | https://dx.doi.org/10.1002/ardp.201000172 | |
dc.identifier.uri | https://hdl.handle.net/11421/13595 | |
dc.description | WOS: 000289418300008 | en_US |
dc.description | PubMed ID: 21469176 | en_US |
dc.description.abstract | In the present study a new series of benzimidazole derivatives bearing various (benz)azolylthio moieties were synthesized so as to investigate their antimicrobial activity. Structures of the target compounds (5a-5i) were confirmed by their IR, (1)H-NMR, ES-MS spectral data, and elemental analyses. The synthesized compounds (5a-5i) exhibited poor activity against bacterial strains. On the other hand, antifungal activity of the compounds against Candida species was very significant. Brine-Shrimp lethality assay was performed for determination of toxicity of the compounds. Compounds 5a, 5c, and 5d were evaluated as non-toxic in addition to their attractive antifungal activity. However, the other compounds (5b, e-i) in the series showed toxicity to different extents. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.relation.isversionof | 10.1002/ardp.201000172 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | (Benz)Azolylthio | en_US |
dc.subject | Benzimidazole | en_US |
dc.subject | Brine-Shrimp Lethality Assay | en_US |
dc.subject | Candida Species | en_US |
dc.title | Antimicrobial Activity of a New Combination System of Benzimidazole and Various Azoles | en_US |
dc.type | article | en_US |
dc.relation.journal | Archiv Der Pharmazie | en_US |
dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı | en_US |
dc.identifier.volume | 344 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 264 | en_US |
dc.identifier.endpage | 271 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.institutionauthor | Özkay, Yusuf | |
dc.contributor.institutionauthor | Tunalı, Yağmur | |