Synthesis and Antimicrobial Evaluation of Some 2,5-Disubstituted Benzimidazole Derivatives

Abstract

Some benzimidazole derivatives bearing hydrazone moiety were synthesized and their in vitro antimicrobial activity was determined against various gram-positive and gram-negative bacteria, and fungi using microbroth dilution method. The structures of all new compounds were identified by H-1-NMR, FT-IR, MS spectroscopic techniques and elemental analysis. Sixteen final products were examined for their in vitro antimicrobial activities. When compared to the reference agents, chloramphenicol and ketoconazole, most of the synthesized compounds showed sufficient antibacterial activity against Pseudomonas aeruginosa and antifungal activity against Candida albicans and C. glabrata.