Synthesis and antimicrobial activities of some imidazole substituted indoles

Abstract

The compounds 1-substituted 2-(imidazol-1-yl)-3-(4,5-diarylimidazol-2-yl) indoles 2, I-substituted 2-(imidazol-1-yl)3-(phenanthro[9,10-d]imidazol-2-yl)indoles 3 and 1-substituted 2-(imidazol-1-yl)-3-(benzimidazol-2-yl)indoles 4 have been synthesized from 1-substituted 2-(imidazol-1-yl)-3-formylindole 1. The structural elucidation of the synthesised compounds has been performed by IR, H-1 NMR and mass spectroscopic data and elemental analyses. Antimicrobial activities of the compounds are examined and notable antifungal activity is obtained from some of the compounds as expected in comparison with the control agent ketoconazole.