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Reproductive toxic effects and possible mechanisms of zonisamide in male rats
(SAGE Publications Ltd, 2019)Zonisamide (ZNS) is an anticonvulsant which is used to treat the symptoms of epilepsy. Although it is frequently used during reproductive ages, studies that investigated the effects of ZNS on reproductive system are limited. ... -
Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress
(Public Library Science, 2017)Levetiracetam (LEV) is an antiepileptic drug commonly used in the treatment of epilepsy because of its excellent safety profile in all age groups. It is remarkable that there are no studies evaluating the toxic effects of ... -
Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms
(Wolters Kluwer Medknow Publications, 2017)This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg ... -
Studies on controlled release dimenhydrinate from matrix tablet formulations
(1999)In this study, controlled release dosage forms of dimenhydrinate were prepared with different polymers as MC, HEC, Carbopol 934, Eudragit RLPM and Eudragit NE 30 D at different concentrations (2.5-10%). Direct compression ... -
Synthesis and MAO inhibitory activity of novel thiazole-hydrazones
(Scientific Technical Research Council Turkey-Tubitak, 2017)A series of new thiazole-hydrazones (3a-3n) were synthesized, characterized, and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method. Selectivity indexes (SIs) were expressed as IC50 ... -
Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress
(Hindawi LTD, 2018)Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one ... -
Validated reversed phase HPLC method for the analysis of the food additive, sodium benzoate, in soft drinks and jams
(Taylor & Francis Inc, 2007)A rapid, simple, and sensitive method is described for the determination of the food preservative sodium benzoate in soft drinks, various jams, and ketchup. The method utilizes high performance liquid chromatography followed ...