| dc.contributor.author | Başaran, Ebru | |
| dc.contributor.author | Demirel, Müzeyyen | |
| dc.contributor.author | Sırmagül, Başar | |
| dc.contributor.author | Yazan, Yasemin | |
| dc.date.accessioned | 2019-10-19T16:02:36Z | |
| dc.date.available | 2019-10-19T16:02:36Z | |
| dc.date.issued | 2011 | |
| dc.identifier.issn | 1550-7033 | |
| dc.identifier.issn | 1550-7041 | |
| dc.identifier.uri | https://dx.doi.org/10.1166/jbn.2011.1325 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13831 | |
| dc.description | WOS: 000296996200013 | en_US |
| dc.description | PubMed ID: 22195490 | en_US |
| dc.description.abstract | In the present study, cyclosporine A (CsA) was incorporated successfully into cationic Eudragit(R) RS 100 nanoparticles (EPNs) aiming ocular application. Physicochemical characterization of the EPNs prepared was performed during the storage period of 6 months. Following in vitro release tests, sheep were used in in vivo studies where 100 mu L of formulation was applied to both eyes (n = 6) under veterinarian supervision. Aqueous and vitreous humour samples were collected at predetermined time intervals and analyzed by enzyme immune assay (EIA). In vitro relase studies showed the extended release of the incorporated drug from the nanoparticles. However in vivo results demonstrated the prolonged residence time of CsA in the deeper layers (vitreous humour) of the eye with positively charged EPNs. | en_US |
| dc.description.sponsorship | Anadolu University Scientific Research Project Foundation [040342] | en_US |
| dc.description.sponsorship | The authors would like to thank ophthalmologists Professor Dr. NilgunYildirim and Professor Dr. Hikmet Basmak for their advisory and to Mehmet Dincer (veterinarian) for professional assistance in the in vivo studies. Colleagues at the Faculty of Engineering and Architecture, Department of Materials Science and Engineering is acknowledged for XRD and PS/ZP analyses and AUBIBAM for TEM, FT-IR and <SUP>1</SUP>H-NMR analysis facilities. This study was financed by Anadolu University Scientific Research Project Foundation (No: 040342). | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Amer Scientific Publishers | en_US |
| dc.relation.isversionof | 10.1166/jbn.2011.1325 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Cyclosporine A | en_US |
| dc.subject | Eudragit (R) As 100 | en_US |
| dc.subject | Cationic Nanoparticles | en_US |
| dc.subject | Ocular Application | en_US |
| dc.title | Polymeric Cyclosporine-A Nanoparticles for Ocular Application | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Journal of Biomedical Nanotechnology | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı | en_US |
| dc.identifier.volume | 7 | en_US |
| dc.identifier.issue | 5 | en_US |
| dc.identifier.startpage | 714 | en_US |
| dc.identifier.endpage | 723 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US] |
| dc.contributor.institutionauthor | Demirel, Müzeyyen | |
| dc.contributor.institutionauthor | Yazan, Yasemin | |
