Sustained release wax matrix formulations of ketorolac tromethamine with Compritol 888 ATO and HD 5 ATO

Abstract

Sustained release wax matrix tablets of ketorolac tromethamine (KT) were prepared with different concentrations of Compritol 888 ATO (Glyceryl behenate) and HD 5 ATO (Glyceryl and Polyethylene glycol behenate). Tablet matrix systems containing Compritol have extensively been used in oral sustained-release drug delivery system formulations. Direct compression tecnique was used to prepare the tablets and the effect release of excipients and their concentrations on drug were investigated. Physical controls and in vitro dissolution techniques were performed for quality assesment. Dissolution profiles of the tablets were plotted and evaluated kinetically.