Improvement in the dissolution properties of theophylline with ß-cyclodextrin

Abstract

An improvement in the dissolution of theophylline with ß-cyclodextrin was achieved by subjecting them to co-grinding and freeze-drying methods. The products obtained were examined by the phase solubility methad, differential scanning calorimetry and X-ray diffractometry. The products thus prepared were evaluated with respect to their dissolution behaviour and particle sizes, and compared with the pure drug and the physical mixture of theophylline and ß-cyclodextrin. The improvement in the dissolution profile of theophylline in the interacted form may be due to its amorphous state, to increased wettability, or to the formation of an inclusion complex.