Kurum Yazarı "Benkli, Kadriye" Makale Koleksiyonu İçin Listeleme
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Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes
Varol, Mehmet; Koparal, Ayşe Tansu; Benkli, Kadriye; Bostancıoğlu, Rakibe Beklem (Bentham Science Publ LTD, 2018)Background: Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the long-term side effects. Objective: A ... -
Biological activities of Cu(II) and Hg(II) complexes of a heptadentate Schiff base ligand
Ergene, Emel; Sivas, Hülya; Benkli, Kadriye (Tubitak Scientific & Technical Research Council Turkey, 2010)Two metal complexes were synthesized as [Hg(L)](ClO4)(2) and [Cu(L)](ClO4), by the template reaction between 2,6-bis(2-aminothiophenoxymethyl)pyridine and 2,2'-bipyridine-6,6'-dicarboxaldehyde in the presence of Hg(II) and ... -
Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents
Varol, Mehmet; Benkli, Kadriye; Koparal, Ayşe Tansu; Bostancıoğlu, Rakibe Beklem (Taylor & Francis LTD, 2019)Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. ... -
Gold(III) compounds-mediated inhibition of lung cancer cell proliferation
Bostancıoğlu, R. Beklem; Kaya, Murat; Koparal, Ayşe Tansu; Benkli, Kadriye (Lippincott Williams & Wilkins, 2016)Research on chemotherapeutics for lung cancer is crucial for designing a new therapeutic strategy against malignant lung tumors. Although radiotherapy and chemotherapy, which are not selective for cancer cells and exert ... -
The in vitro assessment of dipyridophenazine complexes in H-ras oncogene transformed rat embryo fibroblast 5RP7 cell line
Kaplan, Ayşe; Benkli, Kadriye; Koparal, Ayşe Tansu (Springer, 2018)Purpose The aim of this study is to detect apoptotic and cytotoxic/antiproliferative effects of a ligand substance and its metal derivatives. The substances were investigated by using an h-ras oncogene transformed rat ... -
Investigation of Genotoxic Effects of Some Ruthenium Complexes According to Cis-platinum
Alanyalı, Feriştah; Ergin, E.; Artagan, Oge; Benkli, Kadriye (Asian Network Scientific Information-Ansinet, 2011)The aim of our study was, to synthesize and evaluate the mutagenicity of Ruthenium complexes, on Salmonella strains of TA100 and TA98 by Ames Test. [Ru(L)(2)(B)Pt] Cl-2 complexes were synthesized using 1, 10-phenanthroli ... -
Investigation of the pharmacological profiles of dinuclear metal complexes as novel, potent and selective cytotoxic agents against leas-transformed cells
Bostancıoğlu, R. Beklem; Koparal, Ayşe Tansu; Benkli, Kadriye (Elsevier Science BV, 2014)Around the world scientists try to design successful cures against still incurable diseases, especially cancers. New targets for prevention and new agents for therapy need to be identified. We synthesized novel metal ... -
Studies on the cytotoxic, apoptotic and antitumoral effects of Au(III) and Pt(II) complexes of 1, 10-phenanthroline on V79 379A and A549 cell lines
Bostancıoğlu, R. Beklem; Işık, Kenan; Genç, Hatice; Benkli, Kadriye; Koparal, Ayşe Tansu (Informa Healthcare, 2012)In the present study, Au(III) and Pt(II) complexes of 1, 10-phenanthroline (phen) were synthesized and used as the test compounds. The structure elucidation of the synthesized compounds was performed by IR, H-1-NMR and ...