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dc.contributor.authorCengiz, Mustafa
dc.contributor.authorAyhanci, Adnan
dc.contributor.authorKutlu, Hatice Mehtap
dc.contributor.authorMusmul, Ahmet
dc.date.accessioned2019-10-20T08:00:27Z
dc.date.available2019-10-20T08:00:27Z
dc.date.issued2016
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.urihttps://dx.doi.org/10.3906/biy-1506-75
dc.identifier.urihttps://hdl.handle.net/11421/16078
dc.descriptionWOS: 000378689600010en_US
dc.description.abstractSilymarin (Sm) is widely used in treating diseases that affect organs such as the liver, kidney, and gallbladder thanks to its antioxidative, renoprotective, antihepatotoxic, and anticarcinogenic properties. However, this substance is poorly solved in water and tends to decompose in the intestine, its bioavailability decreasing before it can show real effect. With these limitations in mind, the present study aims to enhance the poor bioavailability of Sm by forming Sm-loaded solid lipid nanoparticles (Sm-SLNs) using the hot homogenization method. A characterization process was undertaken to determine possible impact of Sm on experimental kidney damage. Our biochemical and light microscopic results suggest that the group that received Sm-SLNs for the treatment of D-GalN/TNF-alpha-induced experimental kidney damage showed significantly more improvement than the group that received commercially available Sm. In conclusion, Sm-loaded SLN may be a useful system for the delivery of poorly water-soluble Sm and may also provide renoprotection.en_US
dc.description.sponsorshipAnadolu University Scientific Research Project Unit [1305F091]en_US
dc.description.sponsorshipThis work was supported by the Anadolu University Scientific Research Project Unit (project no.: 1305F091).en_US
dc.language.isoengen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.isversionof10.3906/biy-1506-75en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectD-Galn/Tnf-Alphaen_US
dc.subjectKidney Damageen_US
dc.subjectSilymarinen_US
dc.subjectSolid Lipid Nanoparticleen_US
dc.subjectRenoprotectivityen_US
dc.titlePotential therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluationen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Biologyen_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.identifier.volume40en_US
dc.identifier.issue4en_US
dc.identifier.startpage807en_US
dc.identifier.endpage814en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorKutlu, Hatice Mehtap


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