Investigation of cytogenetic effects of 2, 4, 5 triphenyl imidazole by rat bone marrow micronucleus test

Abstract

The cytogenetic effects of 2, 4, 5 triphenyl imidazole on the micronucleus formation were investigated in rats. Increasing doses of the substance were injected i.p. into Wistar rats and polychromatic and normochromatic erythrocytes were scored for the formation of micronuclei in bone marrow smears. The number of micronuclei was found about 2-3 times more in 2,4,5 triphenyl imidazole treated rats than the control groups. This increase in the formation of micronucleus indicates the clastogenic effects of the substance on rats and may have similar effects on other mammals and human population.