| dc.contributor.author | Sidir, Yadigar Gülseven | |
| dc.contributor.author | Sidir, İsa | |
| dc.contributor.author | Berber, Halil | |
| dc.date.accessioned | 2019-10-20T09:02:59Z | |
| dc.date.available | 2019-10-20T09:02:59Z | |
| dc.date.issued | 2011 | |
| dc.identifier.issn | 1089-5639 | |
| dc.identifier.uri | https://dx.doi.org/10.1021/jp2018549 | |
| dc.identifier.uri | https://hdl.handle.net/11421/16588 | |
| dc.description | WOS: 000290652000012 | en_US |
| dc.description | PubMed ID: 21534535 | en_US |
| dc.description.abstract | The acid dissociation constants of twelve novel drug precursor N-substituted-6-acylbenzothiazolone derivatives were determined by using the UV-vis spectroscopic technique. The protonation and deprotonation behaviors of the investigated molecules were researched from the super basic to super acid regions (i.e., 8 mol.L(-1) KOH to 98% H(2)SO(4)) including the pH region. It is observed that all of the molecules are protonated in the super acidic region. The calculated relative stability values of possible tautomer structures indicate that the keto form of investigated molecules is favored over the enol form. It was predicted that protonation occurs at the amide (oxo) group found in the keto form. | en_US |
| dc.description.sponsorship | Turkish Scientific Council (TUB ITAK); [108T192] | en_US |
| dc.description.sponsorship | This work is dedicated to the memory of our colleague Professor Cemil Ogretir, who died on January 19, 2011. Professor Cemil Ogretir's primary contributions have been in determining acidity constants of novel biologically active compounds and in developing novel drugs. Professor Ogretir has been very involved in graduate student education. He has also been involved in international activities and is known with the worthy contributions in these areas. We are grateful to Turkish Scientific Council (TUB ITAK) for the financial support to this work via the Research Project with the number of 108T192. We would like to thank Associated Professor Doctor Ahmet Cabuk and his PhD student Serap Gedikli for support with the UV-2550 Shimadzu UV-vis spectrophotometer. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.relation.isversionof | 10.1021/jp2018549 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Spectroscopic Determination of Acid Dissociation Constants of N-Substituted-6-acylbenzothiazolone Derivatives | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Journal of Physical Chemistry A | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Fen Fakültesi, Fizik Bölümü | en_US |
| dc.identifier.volume | 115 | en_US |
| dc.identifier.issue | 20 | en_US |
| dc.identifier.startpage | 5112 | en_US |
| dc.identifier.endpage | 5117 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.institutionauthor | Berber, Halil | |
