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dc.contributor.authorSidir, Yadigar Gülseven
dc.contributor.authorSidir, İsa
dc.contributor.authorBerber, Halil
dc.date.accessioned2019-10-20T09:02:59Z
dc.date.available2019-10-20T09:02:59Z
dc.date.issued2011
dc.identifier.issn1089-5639
dc.identifier.urihttps://dx.doi.org/10.1021/jp2018549
dc.identifier.urihttps://hdl.handle.net/11421/16588
dc.descriptionWOS: 000290652000012en_US
dc.descriptionPubMed ID: 21534535en_US
dc.description.abstractThe acid dissociation constants of twelve novel drug precursor N-substituted-6-acylbenzothiazolone derivatives were determined by using the UV-vis spectroscopic technique. The protonation and deprotonation behaviors of the investigated molecules were researched from the super basic to super acid regions (i.e., 8 mol.L(-1) KOH to 98% H(2)SO(4)) including the pH region. It is observed that all of the molecules are protonated in the super acidic region. The calculated relative stability values of possible tautomer structures indicate that the keto form of investigated molecules is favored over the enol form. It was predicted that protonation occurs at the amide (oxo) group found in the keto form.en_US
dc.description.sponsorshipTurkish Scientific Council (TUB ITAK); [108T192]en_US
dc.description.sponsorshipThis work is dedicated to the memory of our colleague Professor Cemil Ogretir, who died on January 19, 2011. Professor Cemil Ogretir's primary contributions have been in determining acidity constants of novel biologically active compounds and in developing novel drugs. Professor Ogretir has been very involved in graduate student education. He has also been involved in international activities and is known with the worthy contributions in these areas. We are grateful to Turkish Scientific Council (TUB ITAK) for the financial support to this work via the Research Project with the number of 108T192. We would like to thank Associated Professor Doctor Ahmet Cabuk and his PhD student Serap Gedikli for support with the UV-2550 Shimadzu UV-vis spectrophotometer.en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionof10.1021/jp2018549en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSpectroscopic Determination of Acid Dissociation Constants of N-Substituted-6-acylbenzothiazolone Derivativesen_US
dc.typearticleen_US
dc.relation.journalJournal of Physical Chemistry Aen_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Fizik Bölümüen_US
dc.identifier.volume115en_US
dc.identifier.issue20en_US
dc.identifier.startpage5112en_US
dc.identifier.endpage5117en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorBerber, Halil


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