Microwave assisted synthesis of ferrocene amides

Abstract

A new microwave assisted synthesis methodology has been presented for the preparation of the ferrocene amides. Ferrocene carboxylic acid was derivatised using direct 1H-Benzotriazole/SOCl(2) methodolgy to prepare N-ferrocenoyl benzotriazole as a new starting material for the functionalization of ferrocene ring. N-ferrocenoyl benzotriazole was reacted with mono- and di-amines under microwave irradiation to prepare ferrocene mono- and di-amides in high purity and in good yield