Stereoselective and regioselective synthesis of N-substituted methyl 2-((azolyl)methyl)-3-arylacrylates from Baylis-Hillman acetates

Abstract

N-Substituted methyl 2-((azolyl)methyl)-3-arylacrylates were synthesized stereo- and regioselectively with one-pot reaction between Baylis-Hillman acetates and a suitable acylazole in the presence of K2CO3 as a base catalyst. The targeted N-substituted azole acrylates were efficiently obtained in good yields (39%-89%).