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dc.contributor.authorYavuz, Handan
dc.contributor.authorPatir, S
dc.contributor.authorSay, Rıdvan
dc.contributor.authorArıca, Y
dc.contributor.authorDenizli, Adil
dc.date.accessioned2019-10-20T09:30:46Z
dc.date.available2019-10-20T09:30:46Z
dc.date.issued2002
dc.identifier.issn0149-6395
dc.identifier.urihttps://dx.doi.org/10.1081/SS-120003502
dc.identifier.urihttps://hdl.handle.net/11421/17452
dc.descriptionWOS: 000176800400005en_US
dc.description.abstractIn this study, we synthesized a novel adsorbent to obtain high protein-adsorption capacity utilizing 2-methacrylamidoalanine (MAAL) containing membrane. Amino acid-ligand MAAL was synthesized by using methacrylochloride and alanine. Then, poly(2-hydroxyethylmethacrylate-co-2-methacrylamidoalanine) [p(HEMA-co-MAAL)] membranes were prepared by UV-initiated photopolymerization of HEMA and MAAL in the presence of an initiator (azobisisobutyronitrile, AIBN). Synthesized MAAL was characterized by nuclear magnetic resonance spectroscopy. p(HEMA-co-MAAL) membranes were characterized by swelling studies, porosimeter, scanning electron microscopy, Fourier transform-infra red spectroscopy, and elemental analysis. These membranes have macropores in the size range 5-10 mum. Different metal ions including Zn(II), Ni(II), Co(II), and Cu(II) were chelated on these membranes. p(HEMA-co-MAAL) were used in the adsorption of human serum albumin (HSA) from aqueous media containing different amounts of albumin (0.1-5.0 mg L-1) and at different pH values (4.0-8.0). The maximum HSA adsorption was observed at pH 5.0. The nonspecific adsorption of HSA on the pHEMA membranes was negligible 0.9 mug cm(-2). MAAL incorporation significantly increased the HSA adsorption (1.76 mg cm(-2)). The HSA adsorption capacities of the metal-incorporated membranes were Greater than that of the p(HEMA-co-MAAL) membranes under the same conditions. Higher HSA adsorption capacity was observed from the human plasma (2.88 mg HSA cm(-2)).en_US
dc.language.isoengen_US
dc.publisherMarcel Dekker Incen_US
dc.relation.isversionof10.1081/SS-120003502en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlbumin Adsorptionen_US
dc.subjectAmino Acid Membranesen_US
dc.subjectPoly(Hema)en_US
dc.subjectMetal Chelatesen_US
dc.titleAffinity separation of plasma proteins using a newly synthesized methacrylamidoalanine incorporated porous pHEMA membranesen_US
dc.typearticleen_US
dc.relation.journalSeparation Science and Technologyen_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Fizik Bölümüen_US
dc.identifier.volume37en_US
dc.identifier.issue9en_US
dc.identifier.startpage2077en_US
dc.identifier.endpage2095en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorSay, Rıdvan


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