New Thiophene Bearing Dimethyl-5-Hydroxy Isophtalate Esters and Their Antimicrobial Activities

Abstract

Thiophene belongs to a class of heterocyclic compounds. In this study, three new dimethyl-5-hydroxy isophtalate derived thiophene esters were successfully synthesized and characterized by FT-IR, Elementel Analysis, 1H-NMR, 13C-NMR and HRMass techniques. Synthesized compounds antimicrobial effects were tested on Staphylococcus aureus (ATCC 25923); Enterococcus faecalis (ATCC 29212); Enterococcus faecalis (ATCC 51922); Klebsiella pneumoniae (ATCC 700603); Pseudomonas aeruginosa (ATCC 27853); Escherichia coli (ATCC 35218); Escherichia coli (ATCC 25922) and Candida albicans (ATCC 90028); Candida glabrata (ATCC 90030); Candida krusei (ATCC 6258); Candida parapsilosis (ATCC 22019). Compound C1 showed the highest antimicrobial activity, possessing the same potential as chloramphenicol against, P. aeruginosa ATCC 27853. According to MTT assays, this compound (C1) was identified as non-toxic.