Yazar "Kutlu, Hatice Mehtap" için Fen Fakültesi listeleme
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Lead toxicity and biochemical characterization of $delta$ - ALAD on endemic prawn, Palaemonetes turcorum
Bu çalışmada kurşunun yurdumuz için endemik olan Palaemonetes turcorum'a toksik etkisi, bu türe ait $delta$ - Amino Levulinik Asit Dehidrataz (ALAD; Porfobilinojen sentaz; E.C.4.2.1.24) enzimi ile etkileşimi ve enzimin ... -
Lead toxicity and biochemical characterization of delta-ALAD on endemic prawn, Palaemonetes turcorum
Ciğerci, İbrahim Hakkı; Konuk, Muhsin; Kutlu, Hatice Mehtap (Foundation Environmental Protection & Research-Fepr, 2010)The aim of this studuy was to determine the toxic effect of lead (Pb) on Palaemonetes turcorum, which is endemic to Turkey, in vivo and its inhibitory effect on its delta-Aminolevulinic acid dehydratase (ALAD; E.C.4.2.1.24) ... -
Melatonin induces antiproliferative activity through modulation of apoptotic pathway in H-ras oncogene transformed 5RP7 cells
Kaplan, Ayşe; Çiftçi, Gülsen Akalın; Kutlu, Hatice Mehtap (Tubitak Scientific & Technical Research Council Turkey, 2015)In the present study, cytotoxic and apoptotic effects of melatonin were investigated on H-ras oncogene transformed rat embryo fibroblast 5RP7 cells. Melatonin inhibited cell growth and induced apoptosis in 5RP7 cells. We ... -
Mutagenic activities of ten imidazole derivatives in Salmonella typhimurium
Aydoğan, Gözde; Kutlu, Hatice Mehtap (Springer, 2007)Ten imidazole derivatives were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100 both in the absence and presence of metabolic activation by the microsomal fraction S9 mix. In a general manner, ... -
Mutagenic potential of water from the Tuz Lake, Turkey
Güven, Kıymet; Kutlu, Hatice Mehtap; Aydoğan Kılıç, Gözde; Mutlu, Mehmet Burçin (Parlar Scientific Publications (PSP), 2008)The mutagenic potential of water samples from the Tuz Lake, Turkey was examined by applying the Salmonella mutagenicity assay (Ames test), using TA 98 and TA 100 strains without metabolic activation. XAD 4 and XAD 16 column ... -
Mutagenicity analysis of water samples from Seydisuyu (Kirka, Turkey) stream under the influence of boron production complex
Kutlu, Hatice Mehtap; Aydoğan, Gözde; Mumcu, Emel (Pergamon-Elsevier Science LTD, 2007)Kirka region in Turkey is naturally high in boron content. There is also a boron production complex in our study area. Although boron was found to be neither genotoxic nor carcinogenic, mutagenicity of boron can still be ... -
Nitrate reduction in Haloferax alexandrinus: the case of assimilatory nitrate reductase
Kılıç, Volkan; Aydoğan-Kılıc, G.; Kutlu, Hatice Mehtap; Maria Martinez-Espinosa, Rosa (Springer Japan Kk, 2017)Haloferax alexandrinus Strain TM JCM 10717(T) = IFO 16590(T) is an extreme halophilic archaeon able to produce significant amounts of canthaxanthin. Its genome sequence has been analysed in this work using bioinformatics ... -
Potential protective effect of resveratrol on acoustic trauma: electron microscopy study
Hanci, D.; Ulusoy, S.; Acar, M.; Burukoğlu, D.; Kutlu, Hatice Mehtap; Muluk, Nuray Bayar; Cingi, Cemal (Verduci Publisher, 2016)OBJECTIVE: To investigate the potential preventive effect of resveratrol in rats exposed to acoustic trauma (AT). MATERIALS AND METHODS: In this experimental study, Wistar albino rats were divided into three groups: Group ... -
The Potential Protective Effects of 2-aminoethyl Diphenylborinate against Inner Ear Acoustic Trauma: Experimental Study Using Transmission and Scanning Electron Microscopy
Kaymakci, Mustafa; Acar, Mustafa; Burukoğlu, Dilek; Kutlu, Hatice Mehtap; Shojaolsadati, Paria; Cingi, Cemal; Muluk, Nuray Bayar (Aves, 2015)OBJECTIVE: In this prospective experimental study, we investigated the preventive effects of 2-aminoethyl diphenylborinate (2-APB) in rats exposed to acoustic trauma (AT). Light microscopic, transmission electron microscopic ... -
Potential Recruiting and Hepatoprotective Effects of Ellagic Acid in D-Galactosamine-Induced Liver Damage in Rats
Cengiz, Mustafa; Ali, Jama Hussein; Kutlu, Hatice Mehtap; Vejselova, Djanan; Ayhanci, Adnan (Zoological Soc Pakistan, 2017)The present study aims to investigate the therapeutic and protective effects of ellagic acid (EA) on the toxicity of the liver induced by D-Galactosamine (D-GaIN) in rats. With this in mind, the rats were categorized into ... -
Potential therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation
Cengiz, Mustafa; Ayhanci, Adnan; Kutlu, Hatice Mehtap; Musmul, Ahmet (Tubitak Scientific & Technical Research Council Turkey, 2016)Silymarin (Sm) is widely used in treating diseases that affect organs such as the liver, kidney, and gallbladder thanks to its antioxidative, renoprotective, antihepatotoxic, and anticarcinogenic properties. However, this ... -
Potential therapeutic effects of silymarin and silymarin-loaded solid lipidnanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation
Silymarin (Sm) is widely used in treating diseases that affect organs such as the liver, kidney, and gallbladder thanks to its antioxidative, renoprotective, antihepatotoxic, and anticarcinogenic properties. However, this ... -
Preparation and characterization of ascorbic acid loaded solid lipid nanoparticles and investigation of their apoptotic effects
Güney, Gamze; Kutlu, Hatice Mehtap; Genç, Lütfi (Elsevier Science BV, 2014)In this paper, ascorbic acid (Vitamin C, AA) known as an antioxidant was successfully incorporated in solid lipid nanoparticles (SLNs) by hot homogenization and efficient delivery of AA to cancer cells. The obtained SLN ... -
Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro
Coşkun, Melis Debreli; Arı, Ferda; Oral, Arzu Yılmaztepe; Sarımahmut, Mehmet; Kutlu, Hatice Mehtap; Yılmaz, Veysel T.; Ulukaya, Engin (Pergamon-Elsevier Science LTD, 2013)Fibrosarcoma is one of the fatal cancer types and there is still not satisfactory success in its treatment despite new drugs. Therefore, the search for a new compound has been going on. It is currently known that some ... -
Protective effects of ellagic acid in D-galactosamine-induced kidney damage in rats
Ayhanci, Adnan; Cengiz, Mustafa; Kutlu, Hatice Mehtap; Vejselova, Djanan (Springer, 2016)d-Galactosamine (d-GalN), which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. d-GalN intoxication also induces renal dysfunction ... -
Salmonella mutagenicity analysis of water samples from Camalti saltern
Kutlu, Hatice Mehtap; Mutlu, M. Burçin; Aydoğan Kılıç, Gözde; Güven, Kıymet (Springer, 2008)Mutagenicity analysis of water samples from Camalti Saltern, Turkey were investigated by applying Salmonella mutagenicity test. Plate incorporation assay was applied in the absence of metabolic activation. XAD 4 and XAD ... -
The Salmonella mutagenicity of water and sediments from the Porsuk River in Turkey
Kutlu, Hatice Mehtap; Aydoğan, Gözde; Susuz, F; Özata, A (Elsevier Science BV, 2004)In this study, water and sediments from the Porsuk River were investigated for their potential mutagenicity in Salmonella typhimurium TA 98 and TA 100 strains by performing Ames test (plate incorporation assay) without ... -
Some biochemical properties of delta-aminolevulinic acid dehydratase in Gammarus pulex
Kutlu, Hatice Mehtap; Sümer, S. (Pergamon-Elsevier Science LTD, 2008)The determination of delta-aminolevulinic acid dehydratase (ALAD; porphobilinogen synthetase, EC 4.2.1.24) activity in aquatic organisms might be a useful marker for the identification of lead exposure. ALADs from the ... -
Structural changes of Artemia parthenogenetica (Bowen and Sterling, 1978) (Branchiopoda-Anostraca) exposed to lead acetate
Kutlu, Hatice Mehtap; İşcan, Arzu; Tanatmış, Mustafa (Pergamon-Elsevier Science LTD, 2008)The cosmopolitan genus Artemia occurs both in saline or hypersaline waters and Artemia species are sensitive indicator organisms for environmental contamination. Scientists propose that the brine shrimp (Artemia) is a very ... -
Titanyum Dioksitin A549 Hücreleri Üzerindeki Apoptotik Etkileri
Metal temelli bileşikler potansiyel etkilerinden ve az toksisiteye neden olduklarından dolayı uzun zamandır kullanılmaktadır. Metal bileşik sisplatin çeşitli kanser türlerine karşı tıbbi olarak kullanılmış ve yan etkiler ...