Yazar "Avan, İlker" için Fen Fakültesi listeleme
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Benzotriazole-Mediated Syntheses of Depsipeptides and Oligoesters
Avan, İlker; Tala, Srinivasa R.; Steel, Peter J.; Katritzky, Alan R. (American Chemical Society, 2011)Reactions of O-Pg(alpha-hydroxyacyl)benzotriazoles with (a) unprotected alpha-hydroxycarboxylic acids, (b) amino acids, and (c) amines afforded, respectively, chirally pure (a) oligoesters, (b) depsidipeptides, and (c) ... -
Benzotriazole-Mediated Synthesis of Aza-peptides: En Route to an Aza-Leuenkephalin Analogue
Abo-Dya, Nader E.; Biswas, Suvendu; Başak, Akash; Avan, İlker; Alamry, Khalid A.; Katritzky, Alan R. (American Chemical Society, 2013)Novel N-(N-Pg-azadipeptidoyl)benzotriazoles 20a-e couple efficiently with alpha-amino acids 21a-e, dipeptides 22a-c, aminoxyacetic acid 23a, depsidipeptide 23b, and alpha-hydroxy-beta-phenylpropionic acid 27 yielding, ... -
Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41
Jiang, Shibo; Tala, Srinivasa R.; Lu, Hong; Zou, Peng; Avan, İlker; İbrahim, Tarek S.; Katritzky, Alan R. (Pergamon-Elsevier Science LTD, 2011)Based on molecular docking analysis of earlier results, we designed a series of 2,5-disubstituted furans/pyrroles (5a-h) as HIV-1 entry inhibitors. Compounds were synthesized by Suzuki-Miyaura cross coupling, followed by ... -
Design, Synthesis, and Biological Activity of Novel 5-((Arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 Fusion Inhibitors Targeting gp41
Jiang, Shibo; Tala, Srinivasa R.; Lu, Hong; Abo-Dya, Nader E.; Avan, İlker; Gyanda, Kapil; Debnath, Asım K. (American Chemical Society, 2011)On the basis of our earlier molecular docking analysis, we designed and synthesized 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones (12a-o) as HIV-1 entry inhibitors. Compounds ... -
Efficient Preparation of Aminoxyacyl Amides, Aminoxy Hybrid Peptides, and alpha-Aminoxy Peptides
Katritzky, Alan R.; Avan, İlker; Tala, Srinivasa R. (American Chemical Society, 2009)N-(Pg-alpha-aminoxy acids) 1a-g are converted to N-(Pg-alpha-aminoxyacyl)benzotriazoles 2a-g, Which react under mild conditions with amines, alpha-amino acids/alpha-dipeptides, and alpha-aminoxy acids to give aminoxyacyl ... -
Microwave-Assisted Synthesis of 2,2 '-Azopyridine-Labeled Amines, Amino Acids, and Peptides
Avan, İlker (Georg Thieme Verlag Kg, 2016)A microwave-assisted procedure for labeling amines, amino acids, and peptides with 2,2'-azopyridines (2,2'-AzPy) is described using the corresponding 2,2'-azopyridine-diacylbenzotriazoles. The efficiency of the procedure ... -
Peptidomimetics via modifications of amino acids and peptide bonds
Avan, İlker; Hall, C. Dennis; Katritzky, Alan R. (Royal Soc Chemistry, 2014)Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, ... -
Photophysics of novel coumarin-labeled depsipeptides in solution: sensing interactions with SDS micelle via TICT model
Biswas, Suvendu; Avan, İlker; Başak, Akash; Abo-Dya, Nader E.; Asiri, Abdullah; Katritzky, Alan R. (Springer Wien, 2013)N-Acylbenzotriazoles enable the synthesis (69-92 % yield) of blue to green fluorescent coumarin-labeled depsidipeptides 8a-f (quantum yields 0.004-0.97) and depsitripeptides 12a-d (quantum yields 0.02-0.96). Detailed ... -
Removal of copper(II) and nickel(II) ions from aqueous solution using non-living lichen Ramalina fraxinea biomass: investigation of kinetics and sorption isotherms
Candan, Mehmet; Tay, Funda; Avan, İlker; Tay, Turgay (Desalination Publ, 2017)Studies in the field of heavy metal ion removal from industrial wastewater using biomass are increasing in number due to highly efficient and cost-effective applications. In this study, we report the use of non-living ... -
Synthesis and antimicrobial investigation of some 5H-pyridazino[4,5-b] indoles
Avan, İlker; Güven, Alaattin; Güven, Kıymet (2013)Synthesis and in vitro antimicrobial activities are reported for a series of 1,3,5-substituted 4-oxo-3,4-dihydro- 5H -pyridazino[4,5- b]indole derivatives. Corresponding pyridazino[4,5- b]indoles were prepared from ethyl ... -
Synthesis and antimicrobial investigation of some 5H-pyridazino[4,5-b]indoles
Avan, İlker; Güven, Alaattin; Güven, Kıymet (Scientific Technical Research Council Turkey-Tubitak, 2013)Synthesis and in vitro antimicrobial activities are reported for a series of 1,3,5-substituted 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indole derivatives. Corresponding pyridazino[4,5-b]indoles were prepared from ethyl ...