Güncel Gönderiler: PubMed İndeksli Yayınlar Koleksiyonu
Toplam kayıt 1498, listelenen: 21-40
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Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases
(Taylor & Francis Ltd, 2020)Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, C-13 NMR, H-1 NMR, LC-MS and ... -
Publication and Citation Analysis of Medical Doctors' Residency Master's Theses Involving Animal Experiments on Rats in Turkey
(Sage Publications Ltd, 2020)The number of non-human animals used in research has increased in line with advances in medical technology, although it has previously been shown that these experiments demonstrate poor human utility. This study aimed to ... -
Inhibition effects of some pesticides and heavy metals on carbonic anhydrase enzyme activity purified from horse mackerel (Trachurus trachurus) gill tissues
(Springer Heidelberg, 2020)The gill tissue is the main site of metabolic enzymes or compensation, with the kidney tissue playing a supporting role. At the gill tissue, carbonic anhydrase enzymes (CAs) catalyze the hydration of CO2 to HCO3- and H+ ... -
Regenerative Effect of Resorbable Scaffold Embedded Boron-Nitride/Hydroxyapatite Nanoparticles in Rat Parietal Bone
(Amer Scientific Publishers, 2020)BN has important roles in several physiological events, including bone growth and immune system. New infection-free cranioplasty and has an osteogenic activities material that are compatible with tissue are being developed. ... -
Solanum vegetable-based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration
(Wiley, 9999)The effects of two Solanum vegetables, S. macrocarpon L. (African eggplant), and S. nigrum L. (black nightshade) on aluminum model of neurodegeneration in Drosophila melanogaster was investigated. Flies were treated with ... -
Treatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: Formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assay
(Academic Press Inc Elsevier Science, 2020)Angiogenesis is a fundamental process of wound healing, embryogenesis etc. but occurs in cancer and chronic inflammation pathologically. HET-CAM assay is a useful, well established and animal alternative test to screen ... -
The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and alpha-Glycosidase: a Perspective for Metabolic Disorders
(Springer, 2020)Pain, as a sensible alarm signal of living organisms to avoid tissue damage, is a common and debilitating consequence of a lot of disorders and diseases. the management of chronic pain is particularly challenging. For pain ... -
The etiology of notalgia paresthetica: a descriptive study of 117 patients
(Springer London Ltd, 9999)Background Notalgia paresthetica (NP) is a neuropathic itching condition unilaterally localized in the midscapular area. It is a common but an underdiagnosed disease, and only a few studies investigating NP etiology with ... -
Levocetirizine Dihydrochloride-Loaded Chitosan Nanoparticles: Formulation and in Vitro Evaluation
(Turkish Pharmacists Assoc, 2020)Objectives: the aim of the present study was to formulate levocetirizine hydrochloride (LCD)-loaded chitosan nanoparticles at submicron level with high entrapment efficiency and prolonged effect for optimizing the plasma ... -
Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for inhibition of acetylcholinesterase and carbonic anhydrase I and II enzymes
(Academic Press Inc Elsevier Science, 2020)A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to ... -
Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies
(Elsevier, 2020)Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as antimicrobial drugs for a long time. in the present study, we investigated in vitro inhibitory activities of benzenesulfonamide derivatives ... -
Antiamnesic effects of tofisopam against scopolamine-induced cognitive impairments in rats
(Pergamon-Elsevier Science Ltd, 2020)In this study, we investigated the potential therapeutic effects of tofisopam, a 2,3-benzodiazepine derivative anxiolytic, on cognitive deficits in rats with scopolamine-induced amnesia. Cognitive performance of the rats ... -
Insecticidal and Biting Deterrent Activities of Magnolia grandiflora Essential Oils and Selected Pure Compounds against Aedes aegypti
(Mdpi, 2020)In our natural products screening program for mosquitoes, we tested essential oils extracted from different plant parts of Magnolia grandiflora L. for their insecticidal and biting deterrent activities against Aedes aegypti. ... -
An in vitro investigation of genotoxic effects of dexketoprofen trometamol on healthy human lymphocytes
(Taylor & Francis Ltd, 2020)Non-steroidal anti-inflammatory drugs are drugs with analgesic, antipyretic, and anti-inflammatory effects. This study uses in vitro methods to investigate the potential and unknown genotoxic effects of dexketoprofen ... -
Caffeoylquinic Acids, Cytotoxic, Antioxidant, Acetylcholinesterase and Tyrosinase Enzyme Inhibitory Activities of Six Inula Species from Bulgaria
(Wiley-V C H Verlag Gmbh, 2020)Chlorogenic (5-CQA), 1,5-, 3,5-, 4,5- and 3,4-dicaffeoylquinic (DCQA) acids were identified and quantified in the methanol extracts of Inula oculus-christi L., I. bifrons L., I. aschersoniana Janka var. aschersoniana, I. ... -
Synthesis and docking study of benzimidazole-triazolothiadiazine hybrids as aromatase inhibitors
(Wiley-V C H Verlag Gmbh, 2020)Aromatase is involved in the biosynthesis of estrogen and thus is a critical target for breast cancer. in this study, to identify new aromatase enzyme inhibitors, seven 3-[4-(5-methyl-1H-benzo[d]imidazol-2-yl)phenyl]-6-( ... -
Calcium channel blockers: molecular docking and inhibition studies on carbonic anhydrase I and II isoenzymes
(Taylor & Francis Inc, 9999)Carbonic anhydrases (CAs) are potent dehydration of carbonic acid and catalyst of the reversible hydration of carbon dioxide. Here, CA I and CA II was purified from human erythrocytes using the simple chromatographic method ... -
Carbonic anhydrase, obstructive sleep apnea and hypertension: Effects of intervention
(Wiley, 2020)Whole blood carbonic anhydrase activity (CAa) is increased in patients with obstructive sleep apnea (OSA). Our study investigated the influence of positive airway pressure (PAP) or CA inhibitor acetazolamide (ACT) therapy ... -
Physicochemical characterization and pharmacokinetic evaluation of rosuvastatin calcium incorporated solid lipid nanoparticles
(Elsevier, 2020)Rosuvastatin calcium (RCa) is a very efficient antihyperlipidemic agent, however, being a BCS class II drug, results in poor oral bioavailability. the present study focused on the enhancement of oral bioavailability of RCa ... -
Catecholaminergic and opioidergic system mediated effects of reboxetine on diabetic neuropathic pain
(Springer, 2020)Rationale Current data indicate that the noradrenergic system plays a critical role in neuropathic pain treatment. Notably, drugs that directly affect this system may have curative potential in neuropathy-associated pain. ...
